电休克治疗对严重精神障碍患者炎症标志物的影响。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-01-16 DOI:10.1016/j.jpsychires.2025.01.036

Simge Seren Kirlioglu Balcioglu, Amine Kilictutan, Duygu Ozer, Oya Guclu, Mustafa Nuray Namli

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引用次数: 0

摘要

目的：评价电惊厥治疗（ECT）对重度精神障碍患者全身炎症标志物的影响，并确定治疗反应的潜在临床预测因素。方法：目前的回顾性队列研究包括156例接受ECT治疗的精神病和情绪障碍患者。收集ect前和ect后的血液样本以评估炎症标志物，包括c反应蛋白（CRP）、中性粒细胞-淋巴细胞比率（NLR）和其他全血细胞计数衍生指标。临床结果采用简短精神病学评定量表（BPRS）和临床总体印象严重程度（CGI-S）进行测量。结果：经ECT治疗后，几种炎症标志物显著降低，包括NLR、单核细胞-淋巴细胞比率（MLR）、血小板-淋巴细胞比率（PLR）、CRP和CRP-白蛋白比率。ect后BPRS和CGI-S评分均有明显改善。精神病性表现被确定为更大的症状改善的预测因子；炎症标志物的变化与临床结果无显著相关。结论：ECT可减轻重度精神障碍患者的全身炎症；然而，这种减少可能并不直接对应于临床改善。这些发现表明炎症在电痉挛疗法的治疗效果中起着复杂的作用。

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Impact of electroconvulsive therapy on inflammatory markers in patients with severe mental disorders.

Objective: Evaluation of the effects of electroconvulsive therapy (ECT) on systemic inflammatory markers in patients with severe mental disorders and determination of potential clinical predictors of treatment response.

Methods: The current retrospective cohort study included 156 patients with psychotic and mood disorders who underwent ECT. Pre- and post-ECT blood samples were collected to assess inflammatory markers, including C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), and other complete blood count derived indices. Clinical outcomes were measured using the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression Severity (CGI-S).

Results: Significant reductions in several inflammatory markers were identified, including NLR, monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), CRP and CRP-albumin ratio, following ECT. Both BPRS and CGI-S scores also showed marked improvement post-ECT. Psychotic presentation was identified as a predictor of greater symptom improvement; changes in inflammatory markers were not significantly correlated with clinical outcomes.

Conclusion: ECT can reduce systemic inflammation in patients with severe mental disorders; however, this reduction may not directly correspond to clinical improvement. These findings suggest that inflammation plays a complex role in the therapeutic effects of ECT.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;