Mathias Jacobsen Bach, Mia E Larsen, Amanda O Kellberg, Alexander C Henriksen, Stefan Fuglsang, Inge Lise Rasmussen, Markus Nowak Lonsdale, Mark Lubberink, Lisbeth Marner
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引用次数: 0
摘要
获得动脉输入函数（AIF）对于使用[15O]H2O PET进行定量区域性脑灌注（rCBF）测量至关重要。然而，动脉血液取样是侵入性的，使扫描过程复杂化。我们提出了一种新的非侵入性双扫描技术，该技术具有来自额外心脏扫描的图像衍生输入功能（IDIF）。6例患者和2例健康人分别进行了[15O]H2O PET显像：1)基线时心脏和大脑，2)乙酰唑胺输注后心脏和大脑。从心脏左心室提取IDIF并与AIF进行比较。比较双侧皮质6个区域的rCBF。aif和idif表现出强烈的一致性。rCBF与AIF和IDIF的基线rCBF有很强的相关性(R2 = 0.99，斜率= 0.89 CI: [0.87；0.91], p 2 = 0.98,斜率= 0.93,CI: [0.90, 0.97], p
Non-invasive [15O]H2O PET measurements of cerebral perfusion and cerebrovascular reactivity using an additional heart scan.
Obtaining the arterial input function (AIF) is essential for quantitative regional cerebral perfusion (rCBF) measurements using [15O]H2O PET. However, arterial blood sampling is invasive and complicates the scanning procedure. We propose a new non-invasive dual scan technique with an image derived input function (IDIF) from an additional heart scan. Six patients and two healthy subjects underwent [15O]H2O PET imaging of 1) heart and brain during baseline, and 2) heart and brain after infusion of acetazolamide. The IDIF was extracted from the left ventricle of the heart and compared to the AIF. The rCBF was compared for six bilateral cortical regions. AIFs and IDIFs showed strong agreement. rCBF with AIF and IDIF showed strong correlation for both baseline rCBF (R2 = 0.99, slope = 0.89 CI: [0.87; 0.91], p < 0.0001) and acetazolamide rCBF (R2 = 0.98, slope = 0.93, CI:[0.90;0.97], p < 0.0001) but showed a positive bias of 0.047 mL/(g·min) [-0.025; +0.119] for baseline and 0.024 [-1.04, +1.53] mL/(g·min) for acetazolamide. In conclusion, the invasive arterial cannulation can be replaced by an additional scan of the heart with a minor bias of rCBF estimation. The method is applicable to all scanner systems.
期刊介绍：
JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.
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