扁桃体切除术对家族性地中海热临床表现的影响。

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology Pub Date : 2025-02-01 DOI:10.1016/j.ijporl.2025.112231

Anwar Abdelatty Ibrahim , Alsayed Abdulmageed Alsayed , Mahmoud Abdelrazek Mahmoud , Attalla Hafez Attalla Hassan , Ahmad Mahmoud Hamdan

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引用次数: 0

摘要

目的：家族性地中海热（FMF）是世界上最常见的遗传性自身炎症性疾病。在病理生理学、基因检测、诊断、合并症、疾病相关损伤和治疗策略方面有一些新的进展。本研究旨在评估扁桃体切除术对FMF疾病严重程度和活动性的影响。方法：前瞻性随机队列研究43例FMF合并慢性扁桃体炎患者，随机分为两组：ⅰ组为病例组，23例患者行扁桃体切除及秋水仙碱药物治疗；第二组为对照组，仅给予秋水仙碱20例。评估并记录每月发作频率和三种症状（如发烧、腹/胸痛和肌肉骨骼痛）的平均持续时间（以天为单位）。结果：两个研究组在治疗后三个月观察到每月发作频率、发烧持续时间、腹/胸痛和肌肉骨骼疼痛的显著减少

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The effect of tonsillectomy on clinical manifestations in Familial Mediterranean fever

Purpose

Familial Mediterranean fever (FMF) is the most prevalent genetic autoinflammatory disease worldwide. There are several novel advancements in pathophysiology, genetic testing, diagnosis, comorbidities, disease-related damage, and treatment strategies. This study aimed to assess the effect of tonsillectomy on FMF disease severity and activity.

Methods

This prospective randomized cohort study was conducted on 43 patients diagnosed with FMF and chronic tonsillitis, who were divided randomly into two groups: Group I, a case group including 23 patients subjected to tonsillectomy and medical treatment using colchicine; Group II, a control group consisting of 20 cases receiving only colchicine. The monthly frequency of the attacks and average duration of the three symptoms, such as fever, abdominal/chest pain, and musculoskeletal pain in days, were evaluated and recorded.

Results

A highly significant reduction in the monthly frequency of attacks, duration of fever, abdominal/chest pain, and musculoskeletal pain was observed three months after management in both study groups (p < 0.00001 for all). Evaluation of the values of both groups revealed a significant increase in the degree of change for the duration of fever, abdominal/chest pain in Group I relative to Group II (p = 0.0003 and 0.006 respectively) and a significant increase in the degree of change for musculoskeletal pain in Group II relative to Group I (p = 0.007). Survival analysis showed a nonsignificant difference between the two groups regarding the resolution of fever, abdominal/chest pain, and musculoskeletal pain at 12, 18, and 24 months (p = 0.26, 0.08, and 0.42, respectively)

Conclusion

Tonsillectomy operation combined with colchicine resulted in a greater but nonsignificant decrease in the monthly frequency of the FMF attacks and a significant greater decrease in the duration of fever and abdominal/chest pain compared with the use of colchicine alone. Further research is recommended to confirm these results on a larger scale.

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来源期刊

International journal of pediatric otorhinolaryngology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.70%

发文量

276

审稿时长

62 days

期刊介绍： The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.