强直性脊柱炎与癌症风险

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases Pub Date : 2025-01-21 DOI:10.1111/1756-185X.70085

Shiuan-Tzuen Su, Yung-Heng Lee, Po-Cheng Shih, James C.-C. Wei

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引用次数: 0

摘要

慢性炎症是强直性脊柱炎（AS）的主要特征，并且与癌症的发生机制密切相关。持续的炎症反应可导致DNA损伤、基因突变和异常细胞增殖，所有这些都可能增加患癌症的风险。我们还探讨了AS生物治疗的使用及其潜在的癌症风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ankylosing Spondylitis and Cancer Risk

Chronic inflammation is a major characteristic of ankylosing spondylitis (AS) and is closely related to the mechanisms of cancer development. Persistent inflammatory responses can lead to DNA damage, gene mutations, and abnormal cell proliferation, all of which may increase the risk of cancer. We also explore the use of biologic therapy of AS and their potential cancer risks.

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来源期刊

International Journal of Rheumatic Diseases RHEUMATOLOGY-

CiteScore

3.70

自引率

4.00%

发文量

362

审稿时长

1 months

期刊介绍： The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.