Roberto Rossotti, Alice Nava, Federico D'Amico, Chiara Baiguera, Diana Fanti, Elvira Inglese, Alessandro Raimondi, Nicholas Brian Bana, Federico Spelzini, Maurizio Bini, Chiara Vismara, Massimo Puoti
{"title":"生殖器支原体发病率的增加是由艾滋病毒感染者和PrEP使用者推动的。","authors":"Roberto Rossotti, Alice Nava, Federico D'Amico, Chiara Baiguera, Diana Fanti, Elvira Inglese, Alessandro Raimondi, Nicholas Brian Bana, Federico Spelzini, Maurizio Bini, Chiara Vismara, Massimo Puoti","doi":"10.1177/09564624251315782","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong><i>Mycoplasma genitalium</i> (MG) is responsible for non-gonococcal urethritis. Our aim is to describe MG positivity rate and incidence in specific populations.</p><p><strong>Methods: </strong>Retrospective, surveillance study included all samples collected from 2018 to 2022. All samples were tested with Anyplex II STI7 (Seegene). Incidence rate (IR) was calculated, incidence rate ratios (IRRs) were assessed using Poisson regression model.</p><p><strong>Results: </strong>The study included 13,504 samples belonging to 7,692 individuals. Overall positivity rate was 2.9% (95%CI 2.6-3.2). Subgroups showed significant differences: 13.6% in PrEP users, 5.2% in STI clinic, 4.6% in people living with HIV (PLWH), 1.2% in Gynecology/Obstetrics Department, 0.5% in Fertility clinic, and 0.5% in the \"Other\" group (<i>p</i> < .001). A significant increasing temporal trend was registered for PLWH. Over a cumulative follow up of 2,554 years, 293 incident infections were registered with an IR of 11.5 per 100PYFU. Departments showed diverse IRs: 7.9 per 100PYFU for PLWH, 30.1 per 100PYFU for PrEP users, 22.7 per 100PYFU for STI clinic. Poisson regression model found a significant increase in incident rates over time in the overall study population driven by PLWH and PrEP users.</p><p><strong>Conclusions: </strong>MG is uncommon in the general population with stable trends, while PLWH and PrEP users exhibit increasing positivity rate and incidence.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251315782"},"PeriodicalIF":1.4000,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Increasing incidence of <i>Mycoplasma genitalium</i> is driven by people living with HIV and PrEP users.\",\"authors\":\"Roberto Rossotti, Alice Nava, Federico D'Amico, Chiara Baiguera, Diana Fanti, Elvira Inglese, Alessandro Raimondi, Nicholas Brian Bana, Federico Spelzini, Maurizio Bini, Chiara Vismara, Massimo Puoti\",\"doi\":\"10.1177/09564624251315782\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong><i>Mycoplasma genitalium</i> (MG) is responsible for non-gonococcal urethritis. Our aim is to describe MG positivity rate and incidence in specific populations.</p><p><strong>Methods: </strong>Retrospective, surveillance study included all samples collected from 2018 to 2022. All samples were tested with Anyplex II STI7 (Seegene). Incidence rate (IR) was calculated, incidence rate ratios (IRRs) were assessed using Poisson regression model.</p><p><strong>Results: </strong>The study included 13,504 samples belonging to 7,692 individuals. Overall positivity rate was 2.9% (95%CI 2.6-3.2). Subgroups showed significant differences: 13.6% in PrEP users, 5.2% in STI clinic, 4.6% in people living with HIV (PLWH), 1.2% in Gynecology/Obstetrics Department, 0.5% in Fertility clinic, and 0.5% in the \\\"Other\\\" group (<i>p</i> < .001). A significant increasing temporal trend was registered for PLWH. Over a cumulative follow up of 2,554 years, 293 incident infections were registered with an IR of 11.5 per 100PYFU. Departments showed diverse IRs: 7.9 per 100PYFU for PLWH, 30.1 per 100PYFU for PrEP users, 22.7 per 100PYFU for STI clinic. Poisson regression model found a significant increase in incident rates over time in the overall study population driven by PLWH and PrEP users.</p><p><strong>Conclusions: </strong>MG is uncommon in the general population with stable trends, while PLWH and PrEP users exhibit increasing positivity rate and incidence.</p>\",\"PeriodicalId\":14408,\"journal\":{\"name\":\"International Journal of STD & AIDS\",\"volume\":\" \",\"pages\":\"9564624251315782\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-01-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of STD & AIDS\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/09564624251315782\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of STD & AIDS","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/09564624251315782","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Increasing incidence of Mycoplasma genitalium is driven by people living with HIV and PrEP users.
Background: Mycoplasma genitalium (MG) is responsible for non-gonococcal urethritis. Our aim is to describe MG positivity rate and incidence in specific populations.
Methods: Retrospective, surveillance study included all samples collected from 2018 to 2022. All samples were tested with Anyplex II STI7 (Seegene). Incidence rate (IR) was calculated, incidence rate ratios (IRRs) were assessed using Poisson regression model.
Results: The study included 13,504 samples belonging to 7,692 individuals. Overall positivity rate was 2.9% (95%CI 2.6-3.2). Subgroups showed significant differences: 13.6% in PrEP users, 5.2% in STI clinic, 4.6% in people living with HIV (PLWH), 1.2% in Gynecology/Obstetrics Department, 0.5% in Fertility clinic, and 0.5% in the "Other" group (p < .001). A significant increasing temporal trend was registered for PLWH. Over a cumulative follow up of 2,554 years, 293 incident infections were registered with an IR of 11.5 per 100PYFU. Departments showed diverse IRs: 7.9 per 100PYFU for PLWH, 30.1 per 100PYFU for PrEP users, 22.7 per 100PYFU for STI clinic. Poisson regression model found a significant increase in incident rates over time in the overall study population driven by PLWH and PrEP users.
Conclusions: MG is uncommon in the general population with stable trends, while PLWH and PrEP users exhibit increasing positivity rate and incidence.
期刊介绍：
The International Journal of STD & AIDS provides a clinically oriented forum for investigating and treating sexually transmissible infections, HIV and AIDS. Publishing original research and practical papers, the journal contains in-depth review articles, short papers, case reports, audit reports, CPD papers and a lively correspondence column. This journal is a member of the Committee on Publication Ethics (COPE).
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