动力控制对双心室辅助循环系统血流动力学和瓣膜功能的影响。

IF 1.4 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Fangqun Wang, Chenyang He, Yiliang Ren, Fan Xu, Litao Ding, Mengping Li
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引用次数: 0

摘要

双心室辅助装置(Biventricular assist devices, BiVAD)能够在心力衰竭时为左右心室提供机械支持,改善血液供应,从而维持患者的生命,提高患者的生活质量。但有证据表明,主动脉瓣功能不全和其他瓣膜病变的发生与BiVAD支持有关。如恒速(CS)控制可能导致阀门完全关闭,失去其正常的阀门功能。瓣膜功能与瓣膜开度的百分比有关,大约是心脏周期的30%。本研究开发了一种基于功率的BiVAD控制模型,通过改变功率来调节马达的转速,以达到保持瓣膜功能和恢复生理性灌注的目的。通过模拟BiVAD恒功率和变功率控制,研究了功率控制器对BiVAD血流动力学和瓣膜功能的影响。在可变功率控制下,模拟不同的心力衰竭和活动水平,以获得BiVAD的关键参数和辅助比率。结果表明,功率控制可以帮助BiVAD辅助心力衰竭患者,功率设置应综合考虑瓣膜功能和生理灌注目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of power-based control on the haemodynamics and valve function of the biventricular assist circulation system.

Biventricular assist devices (BiVAD) are capable of providing mechanical support to the left and right ventricles to improve blood supply in heart failure, thereby maintaining patients' lives and improving their quality of life. But there is evidence that the incidence of aortic valve incompetence and other valvular pathologies is related to BiVAD support. Such as constant speed (CS) control may cause the valve to close completely and lose its normal valve function. The valve function is related to the percentage of valve opening which is approximately 30% of the cardiac cycle. This study developed a power-based control model for BiVAD that could regulate motors' speed by altering the power to satisfy objectives of keeping valve function and restoring physiologic perfusion. The effects of the power-based controller on the hemodynamics and valve function were investigated by simulating BiVAD under constant power and variable power controls. Different heart failure and activity levels were also mimicked under variable power control to obtain the BiVAD's critical parameters and the assist ratios. The results show that the power-based control can help the BiVAD to assist a patient with heart failure, and the power settings should comprehensively consider objectives of valve function and physiologic perfusion.

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来源期刊
International Journal of Artificial Organs
International Journal of Artificial Organs 医学-工程:生物医学
CiteScore
3.40
自引率
5.90%
发文量
92
审稿时长
3 months
期刊介绍: The International Journal of Artificial Organs (IJAO) publishes peer-reviewed research and clinical, experimental and theoretical, contributions to the field of artificial, bioartificial and tissue-engineered organs. The mission of the IJAO is to foster the development and optimization of artificial, bioartificial and tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of all human tissues and organs.
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