Min-Seong Ha, Hyo Youl Moon, Minchul Lee, Jang Soo Yook
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In addition, we measured circulating hormone levels, including C-peptide, resistin, insulin-like growth factor 1 (IGF-1), and growth hormone (GH), in the blood.</p><p><strong>Results: </strong>Body fat percentage (BFP) decreased from 37.61% at pre-EP to 29.16% at post-EP in the obese group, but not in the non-obese group. The EP decreased C-peptide (4.58 ng/mL vs. 2.96 ng/mL, <i>p</i> < 0.001) and resistin levels (14.05 ng/mL vs. 11.06 ng/mL, <i>p</i> < 0.001) in the obese group. After the EP, significant improvement in IGF-1 (non-obese: 265.56 ng/mL vs. 311.81 ng/mL, <i>p</i> < 0.001; obese: 224.74 ng/mL vs. 272.89 ng/mL, <i>p</i> < 0.001) and GH levels (non-obese: 3.91 ng/mL vs. 4.80 ng/mL, <i>p</i> < 0.05; obese: 1.76 ng/mL vs. 2.51 ng/mL, <i>p</i> < 0.05) were observed in both groups. Lower C-peptide levels were associated with BFP (<i>r</i> = 0.447, <i>p</i> = 0.009) and muscle mass (<i>r</i> = -0.385, <i>p</i> = 0.02), whereas enhanced IGF-1 levels correlated with increased muscle strength (<i>r</i> = 0.343, <i>p</i> = 0.05) and cardiovascular fitness (<i>r</i> = 0.347, <i>p</i> = 0.04). Multiple linear regression analysis revealed that cardiovascular fitness variability and BFP in the obese group were determined by C-peptide (β = -0.054, <i>p</i> < 0.001) and IGF-1 levels (β = -2.936, <i>p</i> < 0.05), respectively.</p><p><strong>Discussion: </strong>Exercise may induce positive effects on improvements in body composition and physical fitness, as well as on blood levels of metabolic biochemicals such as C-peptide and IGF-1, in adolescent boys with obesity.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1451427"},"PeriodicalIF":3.2000,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735414/pdf/","citationCount":"0","resultStr":"{\"title\":\"Exercise improves body composition, physical fitness, and blood levels of C-peptide and IGF-1 in 11- to 12-year-old boys with obesity.\",\"authors\":\"Min-Seong Ha, Hyo Youl Moon, Minchul Lee, Jang Soo Yook\",\"doi\":\"10.3389/fphys.2024.1451427\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Exercise is vital in preventing and treating obesity. 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The EP decreased C-peptide (4.58 ng/mL vs. 2.96 ng/mL, <i>p</i> < 0.001) and resistin levels (14.05 ng/mL vs. 11.06 ng/mL, <i>p</i> < 0.001) in the obese group. After the EP, significant improvement in IGF-1 (non-obese: 265.56 ng/mL vs. 311.81 ng/mL, <i>p</i> < 0.001; obese: 224.74 ng/mL vs. 272.89 ng/mL, <i>p</i> < 0.001) and GH levels (non-obese: 3.91 ng/mL vs. 4.80 ng/mL, <i>p</i> < 0.05; obese: 1.76 ng/mL vs. 2.51 ng/mL, <i>p</i> < 0.05) were observed in both groups. Lower C-peptide levels were associated with BFP (<i>r</i> = 0.447, <i>p</i> = 0.009) and muscle mass (<i>r</i> = -0.385, <i>p</i> = 0.02), whereas enhanced IGF-1 levels correlated with increased muscle strength (<i>r</i> = 0.343, <i>p</i> = 0.05) and cardiovascular fitness (<i>r</i> = 0.347, <i>p</i> = 0.04). 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引用次数: 0
摘要
运动对预防和治疗肥胖至关重要。尽管它很重要，但对运动如何在生化水平上影响儿童肥胖的理解是有限的。在这项研究中，我们探讨了为期16周的锻炼计划（EP）对身体成分、身体健康和与肥胖相关的血液激素水平的影响。方法：16名肥胖男孩（n = 16）和17名非肥胖男孩（n = 17）参加了由运动游戏和有氧和阻力运动组成的EP。我们检查了身体成分和身体健康的变化。此外，我们还测量了血液中的循环激素水平，包括c肽、抵抗素、胰岛素样生长因子1 （IGF-1）和生长激素（GH）。结果：肥胖组体脂率（BFP）由ep前的37.61%降至ep后的29.16%，非肥胖组无此变化。EP降低肥胖组c肽（4.58 ng/mL vs. 2.96 ng/mL, p < 0.001）和抵抗素水平（14.05 ng/mL vs. 11.06 ng/mL, p < 0.001）。EP后，IGF-1显著改善(非肥胖：265.56 ng/mL vs. 311.81 ng/mL, p < 0.001；肥胖：224.74 ng/mL vs. 272.89 ng/mL, p < 0.001)和生长激素水平(非肥胖：3.91 ng/mL vs. 4.80 ng/mL, p < 0.05；肥胖：1.76 ng/mL vs. 2.51 ng/mL, p < 0.05)。较低的c肽水平与BFP （r = 0.447, p = 0.009）和肌肉质量（r = -0.385, p = 0.02）相关，而升高的IGF-1水平与肌肉力量（r = 0.343, p = 0.05）和心血管健康（r = 0.347, p = 0.04）相关。多元线性回归分析显示，肥胖组心血管适应度变异和BFP分别由c肽（β = -0.054, p < 0.001）和IGF-1水平（β = -2.936, p < 0.05）决定。讨论：运动可能对改善肥胖青少年的身体组成和身体健康，以及血液中代谢生化物质（如c肽和IGF-1）的水平产生积极影响。
Exercise improves body composition, physical fitness, and blood levels of C-peptide and IGF-1 in 11- to 12-year-old boys with obesity.
Introduction: Exercise is vital in preventing and treating obesity. Despite its importance, the understanding of how exercise influences childhood obesity at the biochemical level is limited. In this study, we explore the effects of a 16-week exercise program (EP) on body composition, physical fitness, and the blood levels of hormones related to obesity.
Methods: Sixteen boys with obesity (n = 16) and seventeen boys without obesity (n = 17) took part in an EP comprising sports games and aerobic and resistance exercises. We examined alterations in body composition and physical fitness. In addition, we measured circulating hormone levels, including C-peptide, resistin, insulin-like growth factor 1 (IGF-1), and growth hormone (GH), in the blood.
Results: Body fat percentage (BFP) decreased from 37.61% at pre-EP to 29.16% at post-EP in the obese group, but not in the non-obese group. The EP decreased C-peptide (4.58 ng/mL vs. 2.96 ng/mL, p < 0.001) and resistin levels (14.05 ng/mL vs. 11.06 ng/mL, p < 0.001) in the obese group. After the EP, significant improvement in IGF-1 (non-obese: 265.56 ng/mL vs. 311.81 ng/mL, p < 0.001; obese: 224.74 ng/mL vs. 272.89 ng/mL, p < 0.001) and GH levels (non-obese: 3.91 ng/mL vs. 4.80 ng/mL, p < 0.05; obese: 1.76 ng/mL vs. 2.51 ng/mL, p < 0.05) were observed in both groups. Lower C-peptide levels were associated with BFP (r = 0.447, p = 0.009) and muscle mass (r = -0.385, p = 0.02), whereas enhanced IGF-1 levels correlated with increased muscle strength (r = 0.343, p = 0.05) and cardiovascular fitness (r = 0.347, p = 0.04). Multiple linear regression analysis revealed that cardiovascular fitness variability and BFP in the obese group were determined by C-peptide (β = -0.054, p < 0.001) and IGF-1 levels (β = -2.936, p < 0.05), respectively.
Discussion: Exercise may induce positive effects on improvements in body composition and physical fitness, as well as on blood levels of metabolic biochemicals such as C-peptide and IGF-1, in adolescent boys with obesity.
期刊介绍：
Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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