Mark B Russell, Drew P Locke, Haley M Adams, Alexander R Pelley, Rojan Saghian, Alexandre S Maekawa, Darcie Stapleton, Grace V Mercer, John G Sled, Lindsay S Cahill
{"title":"小鼠神经退行性变模型的性别特异性超声成像生物标志物。","authors":"Mark B Russell, Drew P Locke, Haley M Adams, Alexander R Pelley, Rojan Saghian, Alexandre S Maekawa, Darcie Stapleton, Grace V Mercer, John G Sled, Lindsay S Cahill","doi":"10.3389/fnagi.2024.1445164","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Early detection of neurodegeneration is essential for optimizing interventions. The highly reproducible progression of neurodegeneration in the decrepit (<i>dcr</i>) mouse allows investigation of early biomarkers and mechanisms of brain injury.</p><p><strong>Methods: </strong>Using high-frequency ultrasound, the common carotid arteries of female and male <i>dcr</i> and control mice were imaged longitudinally at time points bracketing the disease progression (50, 75, and 125 days of age) (<i>n</i> = 6 mice/group/sex).</p><p><strong>Results: </strong>Over the disease time course, the female <i>dcr</i> mice demonstrated increased carotid artery blood flow and pulse wave velocity while the male <i>dcr</i> mice had a decrease in heart rate and no change in carotid artery ultrasound parameters. Early imaging biomarkers were sex-specific, with decreased carotid artery blood flow in female <i>dcr</i> mice and increased carotid artery diameter and decreased pulse wave velocity in males.</p><p><strong>Discussion: </strong>Carotid artery and wave reflection ultrasound is a promising screening tool for early detection of neurodegeneration.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1445164"},"PeriodicalIF":4.1000,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747422/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sex-specific ultrasound imaging biomarkers of neurodegeneration in a mouse model.\",\"authors\":\"Mark B Russell, Drew P Locke, Haley M Adams, Alexander R Pelley, Rojan Saghian, Alexandre S Maekawa, Darcie Stapleton, Grace V Mercer, John G Sled, Lindsay S Cahill\",\"doi\":\"10.3389/fnagi.2024.1445164\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Early detection of neurodegeneration is essential for optimizing interventions. The highly reproducible progression of neurodegeneration in the decrepit (<i>dcr</i>) mouse allows investigation of early biomarkers and mechanisms of brain injury.</p><p><strong>Methods: </strong>Using high-frequency ultrasound, the common carotid arteries of female and male <i>dcr</i> and control mice were imaged longitudinally at time points bracketing the disease progression (50, 75, and 125 days of age) (<i>n</i> = 6 mice/group/sex).</p><p><strong>Results: </strong>Over the disease time course, the female <i>dcr</i> mice demonstrated increased carotid artery blood flow and pulse wave velocity while the male <i>dcr</i> mice had a decrease in heart rate and no change in carotid artery ultrasound parameters. Early imaging biomarkers were sex-specific, with decreased carotid artery blood flow in female <i>dcr</i> mice and increased carotid artery diameter and decreased pulse wave velocity in males.</p><p><strong>Discussion: </strong>Carotid artery and wave reflection ultrasound is a promising screening tool for early detection of neurodegeneration.</p>\",\"PeriodicalId\":12450,\"journal\":{\"name\":\"Frontiers in Aging Neuroscience\",\"volume\":\"16 \",\"pages\":\"1445164\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2025-01-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747422/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Aging Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fnagi.2024.1445164\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Aging Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnagi.2024.1445164","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Sex-specific ultrasound imaging biomarkers of neurodegeneration in a mouse model.
Introduction: Early detection of neurodegeneration is essential for optimizing interventions. The highly reproducible progression of neurodegeneration in the decrepit (dcr) mouse allows investigation of early biomarkers and mechanisms of brain injury.
Methods: Using high-frequency ultrasound, the common carotid arteries of female and male dcr and control mice were imaged longitudinally at time points bracketing the disease progression (50, 75, and 125 days of age) (n = 6 mice/group/sex).
Results: Over the disease time course, the female dcr mice demonstrated increased carotid artery blood flow and pulse wave velocity while the male dcr mice had a decrease in heart rate and no change in carotid artery ultrasound parameters. Early imaging biomarkers were sex-specific, with decreased carotid artery blood flow in female dcr mice and increased carotid artery diameter and decreased pulse wave velocity in males.
Discussion: Carotid artery and wave reflection ultrasound is a promising screening tool for early detection of neurodegeneration.
期刊介绍：
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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