线粒体机械感应：细胞力信号的动力来源。

IF 8.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Biology Pub Date : 2025-01-20 DOI:10.1016/j.cub.2024.12.006

Jorge Oliver-De La Cruz, Pere Roca-Cusachs

引用次数: 0

摘要

机械力通过以前未探索的机制影响线粒体动力学。一项新的研究表明，肌动球蛋白张力通过磷酸化裂变复合体的一个关键组成部分来抑制线粒体裂变，这一事件调节了关键转录因子的核积累。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Mitochondria mechanosensing: The powerhouse fueling cellular force signaling.

Mechanical forces influence mitochondrial dynamics through previously unexplored mechanisms. A new study demonstrates that actomyosin tension inhibits mitochondrial fission by phosphorylating a key component of the fission complex and that this event regulates the nuclear accumulation of critical transcription factors.

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来源期刊

Current Biology 生物-生化与分子生物学

CiteScore

11.80

自引率

2.20%

发文量

869

审稿时长

46 days

期刊介绍： Current Biology is a comprehensive journal that showcases original research in various disciplines of biology. It provides a platform for scientists to disseminate their groundbreaking findings and promotes interdisciplinary communication. The journal publishes articles of general interest, encompassing diverse fields of biology. Moreover, it offers accessible editorial pieces that are specifically designed to enlighten non-specialist readers.