胎儿对有害刺激反应的直接证据：生理和行为反应的系统回顾。

IF 2.2 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Early human development Pub Date : 2025-02-01 DOI:10.1016/j.earlhumdev.2025.106196

Carlo V. Bellieni , Kanwaljeet J.S. Anand

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引用次数: 0

摘要

胎儿疼痛通常使用从生理学和解剖学推断的数据进行辩论；而直接观察胎儿的疼痛反应只在少数情况下使用。我们提出了第一个系统综述来仔细分析这一直接证据。我们的目的是总结基于胎儿对有害刺激反应的直接观察的科学文献。我们检索了17项临床研究，重点是直接观察胎儿对有害刺激的反应。本系统综述表明，胎儿对组织损伤引起的急性疼痛/应激反应的直接试验很少，但仍然为胎儿手术或胎儿侵入性手术的治疗干预提供了信息。目前的证据表明，对胎儿疼痛的反应从妊娠中期开始发展，但需要进一步的高质量研究来证实这些发现并指导临床实践。

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Direct evidence of fetal responses to noxious stimulations: A systematic review of physiological and behavioral reactions

Fetal pain is usually debated using data extrapolated from physiology and anatomy; whereas direct observation of fetal pain reactions is only marginally used. We present the first systematic review to carefully analyse this direct evidence.

Our objective was to summarize the scientific literature based on the direct observation of fetal responses to noxious stimulation.

We retrieved 17 clinical studies focused on the direct observation of fetal responses to noxious stimulation. This systematic review suggests that direct trials of fetal responses to acute pain/stress caused by tissue injury are scarce, but nonetheless informative for therapeutic interventions using fetal surgery or fetal invasive procedures. The current evidence indicates that responses to fetal pain develop from mid-gestation onward, but further high-quality research is needed to confirm these findings and guide clinical practice.

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来源期刊

Early human development 医学-妇产科学

CiteScore

4.40

自引率

4.00%

发文量

100

审稿时长

46 days

期刊介绍： Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival. The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas: Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.