肠道微生物群饮食指数与代谢功能障碍相关的脂肪肝疾病之间的关系：一项横断面研究

IF 3.4 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetology & Metabolic Syndrome Pub Date : 2025-01-17 DOI:10.1186/s13098-025-01589-9

Yangyang Zheng, Jinhui Hou, Shiqi Guo, Jinghai Song

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引用次数: 0

摘要

背景：肠道微生物组与代谢功能障碍相关的脂肪肝（MAFLD）之间的关系已引起越来越多的关注。然而，肠道微生物群膳食指数（DI-GM），一种衡量微生物群多样性的指标，与MAFLD之间的关系尚未得到充分探讨。方法：分析2017-2020年全国健康与营养检查调查（NHANES）的数据，包括7243名参与者。采用加权逻辑回归、限制性三次样条（RCS）和亚组分析来研究DI-GM和MAFLD之间的关系。结果：DI-GM与MAFLD患病率呈显著负相关，DI-GM每增加1点，MAFLD患病率降低6.1% （OR = 0.939, 95% CI: 0.901-0.980）。与DI-GM得分为0-3的个体相比，DI-GM得分为6或更高的个体的调整or为0.794 （95% CI: 0.665-0.947）。RCS分析进一步揭示了DI-GM与mald风险之间的线性关系。此外，亚组分析表明，种族可能会改变DI-GM与MAFLD之间的关系（P为相互作用）。结论：DI-GM与MAFLD患病率呈负相关，种族似乎是这种关系的重要修饰因素。

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The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional study.

Background: The relationship between the gut microbiome and metabolic dysfunction-associated fatty liver disease (MAFLD) has garnered increasing attention. However, the association between the dietary index for gut microbiota (DI-GM), a measure of microbiome diversity, and MAFLD has yet to be fully explored.

Methods: Data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES) were analyzed, including 7243 participants. The association between DI-GM and MAFLD was investigated using weighted logistic regression, restricted cubic spline (RCS), and subgroup analyses.

Results: A notable inverse association was identified between DI-GM and the prevalence of MAFLD, with each 1-point increase in DI-GM corresponding to a 6.1% reduction in MAFLD prevalence (OR = 0.939, 95% CI: 0.901-0.980). Individuals with a DI-GM score of 6 or higher had an adjusted OR of 0.794 (95% CI: 0.665-0.947) compared to those with a DI-GM score of 0-3. RCS analysis further revealed a linear relationship between DI-GM and MAFLD risk. Additionally, subgroup analyses suggested that race may modify the association between DI-GM and MAFLD (P for interaction < 0.05).

Conclusions: DI-GM is inversely associated with MAFLD prevalence, and race appears to be a significant modifier of this relationship.

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.