人参皂苷Rg3在癌症研究中的现状及展望

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Auwal Ibrahim Tanko, Salman Hosawi, Ehssan Moglad, Muhammad Afzal, Nehmat Ghaboura, Sami I Alzareaa, Ahmed Osman, Muhammad Shahid Nadeem, Imran Kazmi
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引用次数: 0

摘要

癌症是世界上最具破坏性的疾病之一,每年影响数百万人。尽管有各种治疗方法,但最终效果并不理想。化疗目前是主要的治疗选择。然而,其严重的副作用、有限的疗效和对药物的耐药性削弱了其潜力。越来越多的证据表明,人参皂苷Rg3是一种从人参植物(人参)中提取的天然化合物,在癌症治疗中具有重要的前景。其提出的机制主要涉及增强免疫、延缓癌细胞增殖和转移、触发细胞凋亡、血管生成、表观遗传修饰、调节上皮间质(EMT)和mirna /lncRNA的转移。此外,rg3 -人参皂苷增强了常规癌症治疗的有效性,并通过协同作用减少了不良反应。本文综述了人参皂苷Rg3在癌症研究中的现状,揭示了其复杂的机制以及通过组合和纳米靶向治疗革新癌症治疗的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ginsenoside Rg3 in Cancer Research: Current Trends and Future Prospects - A Review.

Cancer is one of the most devastating illnesses in the world, impacting millions of individuals every year. Despite various therapies, the final effect is unsatisfactory. Chemotherapy currently dominates as the primary option of treatment. However, its severe adverse effects, limited efficacy, and resistance to drugs undermine its potential. Growing evidence suggests that ginsenoside Rg3, a natural compound obtained from the ginseng plant (Panax ginseng), holds significant promise in cancer therapy. Its proposed mechanisms primarily involve the enhancement of immunity, retardation of cancer cellular proliferation and metastasis, triggering apoptosis, angiogenesis, epigenetic modification, and Regulation of transition of epithelial mesenchyma (EMT) and miRNAs/lncRNA. Furthermore, Rg3-ginsenoside potentiates the effectiveness of conventional treatments of cancer and reduces the adverse effects through synergistic interactions. Ginsenoside Rg3's present status in cancer research is thoroughly reviewed in this article, shedding light on its intricate mechanisms and potential to revolutionize cancer therapy through combinatorial and nano-based targeted therapy.

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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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