Auwal Ibrahim Tanko, Salman Hosawi, Ehssan Moglad, Muhammad Afzal, Nehmat Ghaboura, Sami I Alzareaa, Ahmed Osman, Muhammad Shahid Nadeem, Imran Kazmi
{"title":"人参皂苷Rg3在癌症研究中的现状及展望","authors":"Auwal Ibrahim Tanko, Salman Hosawi, Ehssan Moglad, Muhammad Afzal, Nehmat Ghaboura, Sami I Alzareaa, Ahmed Osman, Muhammad Shahid Nadeem, Imran Kazmi","doi":"10.2174/0109298673333781240924024342","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer is one of the most devastating illnesses in the world, impacting millions of individuals every year. Despite various therapies, the final effect is unsatisfactory. Chemotherapy currently dominates as the primary option of treatment. However, its severe adverse effects, limited efficacy, and resistance to drugs undermine its potential. Growing evidence suggests that ginsenoside Rg3, a natural compound obtained from the ginseng plant (Panax ginseng), holds significant promise in cancer therapy. Its proposed mechanisms primarily involve the enhancement of immunity, retardation of cancer cellular proliferation and metastasis, triggering apoptosis, angiogenesis, epigenetic modification, and Regulation of transition of epithelial mesenchyma (EMT) and miRNAs/lncRNA. Furthermore, Rg3-ginsenoside potentiates the effectiveness of conventional treatments of cancer and reduces the adverse effects through synergistic interactions. Ginsenoside Rg3's present status in cancer research is thoroughly reviewed in this article, shedding light on its intricate mechanisms and potential to revolutionize cancer therapy through combinatorial and nano-based targeted therapy.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ginsenoside Rg3 in Cancer Research: Current Trends and Future Prospects - A Review.\",\"authors\":\"Auwal Ibrahim Tanko, Salman Hosawi, Ehssan Moglad, Muhammad Afzal, Nehmat Ghaboura, Sami I Alzareaa, Ahmed Osman, Muhammad Shahid Nadeem, Imran Kazmi\",\"doi\":\"10.2174/0109298673333781240924024342\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cancer is one of the most devastating illnesses in the world, impacting millions of individuals every year. Despite various therapies, the final effect is unsatisfactory. Chemotherapy currently dominates as the primary option of treatment. However, its severe adverse effects, limited efficacy, and resistance to drugs undermine its potential. Growing evidence suggests that ginsenoside Rg3, a natural compound obtained from the ginseng plant (Panax ginseng), holds significant promise in cancer therapy. Its proposed mechanisms primarily involve the enhancement of immunity, retardation of cancer cellular proliferation and metastasis, triggering apoptosis, angiogenesis, epigenetic modification, and Regulation of transition of epithelial mesenchyma (EMT) and miRNAs/lncRNA. Furthermore, Rg3-ginsenoside potentiates the effectiveness of conventional treatments of cancer and reduces the adverse effects through synergistic interactions. Ginsenoside Rg3's present status in cancer research is thoroughly reviewed in this article, shedding light on its intricate mechanisms and potential to revolutionize cancer therapy through combinatorial and nano-based targeted therapy.</p>\",\"PeriodicalId\":10984,\"journal\":{\"name\":\"Current medicinal chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-01-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current medicinal chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0109298673333781240924024342\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0109298673333781240924024342","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Ginsenoside Rg3 in Cancer Research: Current Trends and Future Prospects - A Review.
Cancer is one of the most devastating illnesses in the world, impacting millions of individuals every year. Despite various therapies, the final effect is unsatisfactory. Chemotherapy currently dominates as the primary option of treatment. However, its severe adverse effects, limited efficacy, and resistance to drugs undermine its potential. Growing evidence suggests that ginsenoside Rg3, a natural compound obtained from the ginseng plant (Panax ginseng), holds significant promise in cancer therapy. Its proposed mechanisms primarily involve the enhancement of immunity, retardation of cancer cellular proliferation and metastasis, triggering apoptosis, angiogenesis, epigenetic modification, and Regulation of transition of epithelial mesenchyma (EMT) and miRNAs/lncRNA. Furthermore, Rg3-ginsenoside potentiates the effectiveness of conventional treatments of cancer and reduces the adverse effects through synergistic interactions. Ginsenoside Rg3's present status in cancer research is thoroughly reviewed in this article, shedding light on its intricate mechanisms and potential to revolutionize cancer therapy through combinatorial and nano-based targeted therapy.
期刊介绍:
Aims & Scope
Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.