3T dilated inception network for enhanced autism spectrum disorder diagnosis using resting-state fMRI data.

Autism spectrum disorder (ASD) is one of the complicated neurodevelopmental disorders that impacts the daily functioning and social interactions of individuals. It includes diverse symptoms and severity levels, making it challenging to diagnose and treat efficiently. Various deep learning (DL) based methods have been developed for diagnosing ASD, which rely heavily on behavioral assessment. However, existing techniques have suffered from poor diagnostic outcomes, higher computational complexity, and overfitting issues. To address these challenges, this research work introduces an innovative framework called 3T Dilated Inception Network (3T-DINet) for effective ASD diagnosis using resting-state functional Magnetic Resonance Imaging (rs-fMRI) images. The proposed 3T-DINet technique designs a 3T dilated inception module that incorporates dilated convolutions along with the inception module, allowing it to extract multi-scale features from brain connectivity patterns. The 3T dilated inception module uses three distinct dilation rates (low, medium, and high) in parallel to determine local, mid-level, and global features from the brain. In addition, the proposed approach implements Residual networks (ResNet) to avoid the vanishing gradient problem and enhance the feature extraction ability. The model is further optimized using a Crossover-based Black Widow Optimization (CBWO) algorithm that fine-tunes the hyperparameters thereby enhancing the overall performance of the model. Further, the performance of the 3T-DINet model is evaluated using the five ASD datasets with distinct evaluation parameters. The proposed 3T-DINet technique achieved superior diagnosis results compared to recent previous works. From this simulation validation, it's clear that the 3T-DINet provides an excellent contribution to early ASD diagnosis and enhances patient treatment outcomes.