Patrick Wesley Marques de Boa, Kaiza de Sousa Santos, Aleph Matthews da Silva Souza, Arnóbio Antônio da Silva-Júnior, Boniek Castillo Dutra Borges
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Data extraction focused on key details, including study design, interventions, and outcomes.</p><p><strong>Results: </strong>Twenty-one articles were reviewed, consisting of nine clinical studies, one in vivo/in situ study, and 11 in vitro studies on tooth bleaching protocols. Hydrogen peroxide was the most commonly used bleaching agent. The primary nanostructured additives studied were titanium dioxide nanoparticles, polymeric carbamide peroxide nanoparticles, chitosan nanoparticles, nano-hydroxyapatite, SiO2/MgO/Fe2O3 nanocomposite spheres, and nano-bioactive glass. Most studies demonstrated an enhanced bleaching effect, reduced bleaching sensitivity, decreased cytotoxicity, reduced hydrogen peroxide penetration into the pulp chamber, and protection of the tooth surface against mineral and structural loss when nanostructured additives were incorporated into the bleaching agent.</p><p><strong>Conclusions: </strong>Incorporating nanostructured additives into tooth-bleaching agents improved efficacy and reduced side effects, especially with titanium oxide nanoparticles. Further clinical studies and systematic reviews are needed to establish strong evidence for safe clinical practice.</p><p><strong>Clinical relevance: </strong>Including nanostructured additives in bleaching agents, such as titanium oxide nanoparticles, might be a valuable approach to enhancing the bleaching potential while reducing bleaching sensitivity and cytotoxicity, offering safer alternatives for clinical protocols.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"70"},"PeriodicalIF":3.1000,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of nanostructured additives in tooth bleaching agents on enhancing color change and reducing side effects: a scoping review.\",\"authors\":\"Patrick Wesley Marques de Boa, Kaiza de Sousa Santos, Aleph Matthews da Silva Souza, Arnóbio Antônio da Silva-Júnior, Boniek Castillo Dutra Borges\",\"doi\":\"10.1007/s00784-025-06148-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aimed to determine whether incorporating nanostructured additives into bleaching agents enhances efficacy and reduces side effects while identifying gaps for further investigation.</p><p><strong>Methods: </strong>A comprehensive search was conducted in electronic databases, including PubMed/Medline, Embase, Scopus, and ISI Web of Science. 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引用次数: 0
摘要
目的：本研究旨在确定在漂白剂中加入纳米结构添加剂是否能提高漂白剂的功效并减少副作用，同时确定有待进一步研究的空白。方法：综合检索PubMed/Medline、Embase、Scopus、ISI Web of Science等电子数据库。两位审稿人根据预先确定的标准独立筛选文章，通过与第三位审稿人讨论或咨询来解决差异。数据提取侧重于关键细节，包括研究设计、干预措施和结果。结果：共回顾了21篇关于牙齿漂白方案的文章，包括9篇临床研究、1篇体内/原位研究和11篇体外研究。双氧水是最常用的漂白剂。研究的主要纳米结构添加剂是二氧化钛纳米颗粒、聚合过氧化脲纳米颗粒、壳聚糖纳米颗粒、纳米羟基磷灰石、SiO2/MgO/Fe2O3纳米复合球和纳米生物活性玻璃。大多数研究表明，当纳米结构添加剂加入漂白剂时，漂白效果增强，漂白敏感性降低，细胞毒性降低，过氧化氢渗透到牙髓腔，保护牙齿表面免受矿物和结构损失。结论：在牙齿漂白剂中加入纳米结构添加剂，尤其是氧化钛纳米添加剂，可以提高牙齿漂白剂的疗效，减少副作用。需要进一步的临床研究和系统评价来为安全的临床实践建立强有力的证据。临床意义：在漂白剂中加入纳米结构添加剂，如氧化钛纳米颗粒，可能是一种有价值的方法，可以增强漂白剂的潜力，同时降低漂白剂的敏感性和细胞毒性，为临床方案提供更安全的替代方案。
Impact of nanostructured additives in tooth bleaching agents on enhancing color change and reducing side effects: a scoping review.
Objectives: This study aimed to determine whether incorporating nanostructured additives into bleaching agents enhances efficacy and reduces side effects while identifying gaps for further investigation.
Methods: A comprehensive search was conducted in electronic databases, including PubMed/Medline, Embase, Scopus, and ISI Web of Science. Two reviewers independently screened articles based on predefined criteria, resolving discrepancies through discussion or consultation with a third reviewer. Data extraction focused on key details, including study design, interventions, and outcomes.
Results: Twenty-one articles were reviewed, consisting of nine clinical studies, one in vivo/in situ study, and 11 in vitro studies on tooth bleaching protocols. Hydrogen peroxide was the most commonly used bleaching agent. The primary nanostructured additives studied were titanium dioxide nanoparticles, polymeric carbamide peroxide nanoparticles, chitosan nanoparticles, nano-hydroxyapatite, SiO2/MgO/Fe2O3 nanocomposite spheres, and nano-bioactive glass. Most studies demonstrated an enhanced bleaching effect, reduced bleaching sensitivity, decreased cytotoxicity, reduced hydrogen peroxide penetration into the pulp chamber, and protection of the tooth surface against mineral and structural loss when nanostructured additives were incorporated into the bleaching agent.
Conclusions: Incorporating nanostructured additives into tooth-bleaching agents improved efficacy and reduced side effects, especially with titanium oxide nanoparticles. Further clinical studies and systematic reviews are needed to establish strong evidence for safe clinical practice.
Clinical relevance: Including nanostructured additives in bleaching agents, such as titanium oxide nanoparticles, might be a valuable approach to enhancing the bleaching potential while reducing bleaching sensitivity and cytotoxicity, offering safer alternatives for clinical protocols.
期刊介绍：
The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.
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