无创正压通气联合压力支持通气治疗慢性心力衰竭疗效的meta分析。

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Clinical Cardiology Pub Date : 2025-01-16 DOI:10.1002/clc.70041

Xiaohong Zhang, Ye Dong, Dongliang Diao, Ming Li

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引用次数: 0

摘要

目的：通过meta分析，评价无创正压通气联合压力支持通气（NPPV-PSV）治疗慢性心力衰竭（CHF）的临床疗效和安全性。方法：系统检索PubMed、Embase、Web of Science、Cochrane Library、CNKI、万方等数据库，查找NPPV-PSV治疗CHF的随机对照试验和队列研究。搜索时间从开始到2024年。符合条件的研究纳入系统评价和荟萃分析。结果：本荟萃分析共纳入8项研究，568例患者。meta分析显示，与常规治疗相比，NPPV-PSV治疗在以下几个方面具有显著优势：临床有效率（总效应Z = 5.10, OR = 3.12, 95%可信区间（CI） [2.01, 4.83], p = 0.000）、心率（HR）（总效应Z = 16.26, MD = -10.50, 95% CI [-11.76, -9.23], p = 0.000）、呼吸速率（RR）（总效应Z = 16.50, MD = -6.44, 95% CI [-7.20, -5.67], p = 0.000）和血氧饱和度（总效应Z = 12.40, MD = 0.09, 95% CI [0.08, 0.11], p = 0.000）。结论：无创正压通气联合PSV治疗可显著改善CHF患者的临床症状，降低HR和RR，提高血氧饱和度，效果优于常规治疗。

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A Meta-Analysis on the Efficacy of Noninvasive Positive Pressure Ventilation Combined With Pressure Support Ventilation in Treating Chronic Heart Failure

Objective

To evaluate the clinical efficacy and safety of noninvasive positive pressure ventilation combined with pressure support ventilation (NPPV-PSV) in the treatment of chronic heart failure (CHF) through a meta-analysis.

Methods

A systematic search was conducted using PubMed, Embase, Web of Science, Cochrane Library, CNKI and Wanfang databases to find randomized controlled trials and cohort studies on NPPV-PSV treatment for CHF. The period of search was set from inception until 2024. Eligible studies were included in a systematic review and meta-analysis.

Results

A total of 8 studies with 568 patients were included in this meta-analysis. The meta-analysis revealed that compared with conventional treatment, NPPV-PSV treatment had significant advantages in several aspects: clinical efficacy rate (total effect Z = 5.10, OR = 3.12, 95% confidence interval (CI) [2.01, 4.83], p = 0.000), heart rate (HR) (total effect Z = 16.26, MD = −10.50, 95% CI [−11.76, −9.23], p = 0.000), respiratory rate (RR) (total effect Z = 16.50, MD = −6.44, 95% CI [−7.20, −5.67], p = 0.000) and oxygen saturation (total effect Z = 12.40, MD = 0.09, 95% CI [0.08, 0.11], p = 0.000).

Conclusion

Noninvasive positive pressure ventilation combined with PSV treatment significantly improves clinical symptoms, reduces HR and RR and increases oxygen saturation in patients with CHF, showing superior effects compared with conventional treatment.

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来源期刊

Clinical Cardiology 医学-心血管系统

CiteScore

5.10

自引率

3.70%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Clinical Cardiology provides a fully Gold Open Access forum for the publication of original clinical research, as well as brief reviews of diagnostic and therapeutic issues in cardiovascular medicine and cardiovascular surgery. The journal includes Clinical Investigations, Reviews, free standing editorials and commentaries, and bonus online-only content. The journal also publishes supplements, Expert Panel Discussions, sponsored clinical Reviews, Trial Designs, and Quality and Outcomes.