八段锦运动辅助治疗膝关节骨性关节炎的疗效和安全性：一项随机对照试验的meta分析。

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine Pub Date : 2025-01-17 DOI:10.1016/j.ctim.2025.103127

Ye Tian , Zi-Yuan Liu , Jia-Hao Wang , Jing-Hua Qian

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引用次数: 0

摘要

目的：通过meta分析，系统评价八段锦运动治疗膝骨性关节炎的疗效和安全性。八段筋作为一种中国传统的运动疗法，属于补充和替代医学的一部分，但由于证据有限，其对膝关节骨关节炎的治疗价值尚不确定。本研究旨在解决这一差距。方法：该研究方案已在PROSPERO注册（CRD42024501559）。通过检索截至2024年1月的6个数据库（PubMed、Cochrane Library、EBSCO、Web of Science and CNKI、万方医学）进行系统综述和meta分析，包括评估八段筋运动治疗KOA的随机对照试验。两位审稿人独立选择研究，提取数据，并使用Cochrane风险偏倚工具（RoB2）评估偏倚风险。采用RevMan 5.4.1版软件进行meta分析。结局指标包括WOMAC膝关节疼痛评分、僵硬评分和身体功能评分，以及总评分和不良事件。对于总结结果，使用加权平均差（MD）和95%置信区间（CI）。结果：纳入12项随机对照试验，共846名受试者。八段锦运动可显著改善WOMAC疼痛评分（MD=-2.59, 95% CI: -4.20 ~ -0.97， P=0.002）、僵硬评分（MD=-2.42, 95% CI: -3.75 ~ - 1.08， P=0.004）、身体功能评分（MD=-4.42, 95% CI: -5.67 ~ -3.17， P）。结论：八段锦运动是改善KOA患者疼痛和功能的有效、安全的补充疗法。需要高质量的随机对照试验来证实这些发现并探索最佳干预参数。未来的研究应解决已确定的方法学局限性。

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The efficacy and safety of Baduanjin exercise as complementary therapy for pain reduction and functional improvement in knee osteoarthritis: A meta-analysis of randomized controlled trials

Objectives

To systematically evaluate the efficacy and safety of Baduanjin exercise in patients with knee osteoarthritis through meta-analysis. While Baduanjin exercise, a traditional Chinese exercise therapy, is part of complementary and alternative medicine, its therapeutic value for knee osteoarthritis remains uncertain due to limited supporting evidence. This study seeks to address this gap.

Methods

The study protocol has been registered in PROSPERO(CRD42024501559). A systematic review and meta-analysis were conducted by searching six databases up to January 2024 (PubMed, Cochrane Library, EBSCO, Web of Science and CNKI, and Wanfang Medical), including RCTs that assessed Baduanjin exercise for KOA treatment. Two reviewers independently selected studies, extracted data, and assessed risk of bias using the Cochrane Risk of Bias tool (RoB2). Meta-analyses were performed using RevMan version 5.4.1 software. The outcome indicators included the WOMAC knee pain score, stiffness score, and physical function score, as well as the total score and adverse events. For summary results, weighted mean difference (MD) and 95 % confidence intervals (CI) were used.

Results

Twelve RCTs involving 846 participants were included. Baduanjin exercise significantly improved WOMAC pain score (MD=-2.59, 95 % CI: −4.20 to −0.97, P = 0.002), stiffness score (MD=-2.42, 95 % CI: −3.75 to - 1.08, P = 0.004), physical function score (MD=-4.42, 95 % CI: −5.67 to −3.17, P < 0.00001), and total score (MD=-11.27, 95 % CI: −14.26 to −8.28, P < 0.00001) compared to controls. Subgroup analyses revealed significant improvements regardless of intervention duration, frequency, or location. No adverse events were reported. However, high heterogeneity and methodological biases were observed.

Conclusion

Baduanjin exercise appears to be an effective and safe complementary therapy for improving pain and function in patients with KOA. High-quality RCTs are needed to confirm these findings and explore optimal intervention parameters. Future research should address the identified methodological limitations.

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来源期刊

Complementary therapies in medicine 医学-全科医学与补充医学

CiteScore

8.60

自引率

2.80%

发文量

101

审稿时长

112 days

期刊介绍： Complementary Therapies in Medicine is an international, peer-reviewed journal that has considerable appeal to anyone who seeks objective and critical information on complementary therapies or who wishes to deepen their understanding of these approaches. It will be of particular interest to healthcare practitioners including family practitioners, complementary therapists, nurses, and physiotherapists; to academics including social scientists and CAM researchers; to healthcare managers; and to patients. Complementary Therapies in Medicine aims to publish valid, relevant and rigorous research and serious discussion articles with the main purpose of improving healthcare.