Xiao Jing Wang, Lindsey Philpot, Jon Ebbert, Saam Dilmaghani, Conor Loftus, Jean Fox, Olafur Palsson
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The intervention combined bloating-targeted hypnotic suggestions and guided diaphragmatic breathing delivered under hypnosis, supplemented with interval self-guided breathing exercises. Participants completed online REDCap assessments at baseline, mid-treatment, at end-of-treatment and at 3-month follow-up, evaluating symptom severity, GI symptom specific anxiety, overall anxiety/depression, and quality of life. Outcomes were assessed in an intention-to-treat manner with repeated measures ANOVAs with Bonferroni-adjusted pairwise post-hoc tests.</p><p><strong>Results: </strong>Of 23 patients who started treatment, 22 (95.6%) completed follow-up. Bloating severity on IBS-SSS and PAGI-SYM showed reduction in bloating with large effect sizes (Cohen's d of ∼0.8) at the end of treatment, as did VSI bloating-related anxiety. At end of treatment, 16 patients (69.6 %) were IBS-SSS treatment responders (>30% symptom reduction) on bloating, and 17 (73.9%) on overall bowel symptom severity. Anxiety, depression, and quality of life scores were unchanged. Outcome measures were fully maintained at 3-month follow-up.</p><p><strong>Conclusions: </strong>Results suggest the therapeutic utility of a new cost-effective self-administered bloating intervention. 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引用次数: 0
摘要
背景与目的：腹胀是一种较难治疗的症状。催眠疗法和横膈膜干预在先前的工作中分别显示出对腹胀的益处，但尚未统一为单一的干预。我们的目的是获得一种新的录音腹胀治疗腹胀整合催眠和横膈膜呼吸的潜在治疗效果的数据，并提出协同效应。方法：以腹胀症状为主要症状的非器质性肠道疾病患者在没有临床医生参与的情况下完成了数字化交付的七期录音催眠治疗计划。干预结合了针对腹胀的催眠建议和催眠下引导的膈肌呼吸，辅以间歇自主呼吸练习。参与者在基线、治疗中期、治疗结束和3个月随访时完成在线REDCap评估，评估症状严重程度、胃肠道症状特异性焦虑、总体焦虑/抑郁和生活质量。结果以意向治疗方式进行评估，采用重复测量方差分析，采用bonferroni校正成对事后检验。结果：23例患者开始治疗，22例（95.6%）完成随访。在治疗结束时，IBS-SSS和PAGI-SYM的腹胀严重程度显示腹胀减轻，且效应量大（Cohen’s d = ~ 0.8）， VSI腹胀相关焦虑也是如此。治疗结束时，16名患者（69.6%）对腹胀有IBS-SSS治疗反应（症状减轻30%），17名患者（73.9%）对整体肠道症状严重程度有反应。焦虑、抑郁和生活质量得分没有变化。结果指标在随访3个月时完全维持。结论：结果表明一种新的具有成本效益的自我管理的腹胀干预的治疗效用。计划进行一项随机对照试验来证实这些治疗效果。
DIGITAL THERAPEUTIC COMBINING HYPNOSIS AND DIAPHRAGMATIC BREATHING INTERVENTION FOR FUNCTIONAL ABDOMINAL BLOATING (FAB): A FEASIBILITY STUDY.
Background and aims: Abdominal bloating is a difficult symptom to treat. Hypnotherapy and diaphragmatic intervention have separately shown benefit on bloating in prior work but have not been united into a single intervention. We aimed to obtain data on the potential therapeutic impact of a novel audio-recorded bloating treatment for bloating integrating hypnosis and diaphragmatic breathing, with proposed synergistic effect.
Methods: Patients with non-organic bowel disorders with predominant bloating symptoms completed a digitally delivered seven-session audio-recorded hypnotherapy program without clinician involvement. The intervention combined bloating-targeted hypnotic suggestions and guided diaphragmatic breathing delivered under hypnosis, supplemented with interval self-guided breathing exercises. Participants completed online REDCap assessments at baseline, mid-treatment, at end-of-treatment and at 3-month follow-up, evaluating symptom severity, GI symptom specific anxiety, overall anxiety/depression, and quality of life. Outcomes were assessed in an intention-to-treat manner with repeated measures ANOVAs with Bonferroni-adjusted pairwise post-hoc tests.
Results: Of 23 patients who started treatment, 22 (95.6%) completed follow-up. Bloating severity on IBS-SSS and PAGI-SYM showed reduction in bloating with large effect sizes (Cohen's d of ∼0.8) at the end of treatment, as did VSI bloating-related anxiety. At end of treatment, 16 patients (69.6 %) were IBS-SSS treatment responders (>30% symptom reduction) on bloating, and 17 (73.9%) on overall bowel symptom severity. Anxiety, depression, and quality of life scores were unchanged. Outcome measures were fully maintained at 3-month follow-up.
Conclusions: Results suggest the therapeutic utility of a new cost-effective self-administered bloating intervention. A randomized controlled trial is planned to confirm these therapeutic effects.
期刊介绍：
Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease.
Colon and small bowel
Endoscopy and novel diagnostics
Esophagus
Functional GI disorders
Immunology of the GI tract
Microbiology of the GI tract
Inflammatory bowel disease
Pancreas and biliary tract
Liver
Pathology
Pediatrics
Preventative medicine
Nutrition/obesity
Stomach.
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