使用Secukinumab治疗的斑块型银屑病患者，尽管避免了温泉暴露，但复发性NTM肺部疾病：一例报告。

IF 3.4 3区医学 Q2 INFECTIOUS DISEASES

BMC Infectious Diseases Pub Date : 2025-01-20 DOI:10.1186/s12879-025-10487-4

Yixiao Wei, Chunlei Wang, Lingtao Chong, Xiaojing Cui

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引用次数: 0

摘要

背景：与Secukinumab治疗相关的复发性非结核性分枝杆菌肺病（NTM-PD）以前没有文献记载。病例介绍：尽管坚持治疗和避免泡温泉，一个斑块型银屑病患者经历了持续的NTM-PD复发。结论：IL-17A抑制剂Secukinumab与NTM疾病存在潜在关联，与抗tnf生物制剂的NTM风险相一致，迫切需要进一步研究其致病机制和危险因素。

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Recurrent NTM pulmonary disease despite avoidance of hot spring exposure in a plaque psoriasis patient treated with Secukinumab: a case report.

Background: Recurrent Non-Tuberculous Mycobacterial Pulmonary Disease (NTM-PD) related to treatment with Secukinumab has not been previously documented.

Case presentation: Despite adherence to treatment and avoiding hot springs, a plaque psoriasis patient experienced persistent NTM-PD relapses.

Conclusions: There is potential association between Secukinumab, an IL-17A inhibitor, and NTM disease, echoing anti-TNF biologics' NTM risk, indicating the urgent need for further research on pathogenic mechanisms and risk factors.

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来源期刊

BMC Infectious Diseases 医学-传染病学

CiteScore

6.50

自引率

0.00%

发文量

860

审稿时长

3.3 months

期刊介绍： BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.