通过将肝性脑病纳入国家退伍军人队列meld3.0来增强肝硬化死亡率预测。

IF 8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

American Journal of Gastroenterology Pub Date : 2025-01-16 DOI:10.14309/ajg.0000000000003317

Scott Silvey, Nilang Patel, Jacqueline G O'Leary, Jasmohan S Bajaj

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引用次数: 0

摘要

尽管有阴性结果，肝性脑病（HE）并未被纳入终末期肝病模型（MELD）评分，包括MELD3.0。在国家退伍军人事务（VA）数据库中，我们研究了75,327名退伍军人（26.8%的HE， 22%的90天死亡率和37%的1年死亡率）住院患者公开HE诊断对MELD3.0和MELD-Na评分的加性死亡率预测影响。在多变量回归中，HE加入MELD3.0和MELD-Na可显著提高其90天和1年的死亡率预测。记录在案的住院患者HE发作可在MELD3.0的死亡率预测中增加4-5分，并可增强未来的MELD迭代。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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ENHANCEMENT OF CIRRHOSIS MORTALITY PREDICTION BY INCLUDING HEPATIC ENCEPHALOPATHY TO MELD3.0 IN A NATIONAL VETERAN COHORT.

Despite negative outcomes, hepatic encephalopathy (HE) is not included in model-for-end-stage liver disease (MELD) scores, including MELD3.0. In a national Veterans affairs (VA) database, we studied the additive mortality predictive impact of a documented inpatient overt HE diagnosis on MELD3.0 and MELD-Na scores in 75,327 Veterans (26.8% with HE, 22% 90-day and 37% 1-year mortality). The addition of HE to MELD3.0 and MELD-Na significantly improved their mortality prediction with interactions at 90-days and 1-year on multivariable regression. A documented inpatient HE episode is additive to the mortality prediction of MELD3.0 by 4-5 extra points and could enhance future MELD iterations.

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来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.