2000-2017年芬兰三个全国性调查和登记数据的新生血管性年龄相关性黄斑变性

IF 3 3区 医学 Q1 OPHTHALMOLOGY
Petri Purola, Seppo Koskinen, Kai Kaarniranta, Hannu Uusitalo
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引用次数: 0

摘要

目的:评估芬兰2000-2017年新生血管性年龄相关性黄斑变性(nAMD)发病率和患病率的时间趋势及其治疗、相关因素和对视力的影响。方法:我们使用了三个全国性的健康检查调查,代表了30岁或以上的芬兰人口。所有三项调查都与2000年至2017年期间涵盖nAMD诊断和玻璃体内注射的国家护理登记册有关。所有三项调查都包括一项健康检查,其中测量了远近视力(VA),以及自我报告和基于登记册的社会人口状况和生活方式、医疗保健使用、合并症和生活质量等信息。数据包括2011年和2017年的两个横断面时间点,以及2000-2011年和2006-2017年的两次11年纵向随访。结果:nAMD在女性中的发病率和患病率是男性的2倍。2011年至2017年期间,nAMD治疗组的年患病率从0.51%上升到0.70%,从0.22%上升到0.46%。接受治疗的nAMD患者每个治疗年平均进行4次玻璃体内注射。结论:由于nAMD是一个日益增加的公共卫生负担,且存在性别差异和对视力的不利影响,我们应该更好地发现发生nAMD的高危患者,并尝试优化其预防干预措施。一旦开发出nAMD,我们应该了解个性化水平的治疗和随访需求。全国登记数据帮助我们应对这些挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neovascular age-related macular degeneration on three nationwide survey and register data in Finland during 2000-2017.

Purpose: To evaluate time trends in the incidence and prevalence of neovascular age-related macular degeneration (nAMD) and its treatments, associated factors, and effects on vision in Finland during 2000-2017.

Methods: We used three nationwide health examination surveys representing the Finnish population aged 30 years or older. All three surveys were linked to the national care register covering nAMD diagnoses and intravitreal injections between 2000 and 2017. All three surveys included a health examination in which distance and near visual acuity (VA) were measured, as well as self-reported and register-based information on socio-demographic status and lifestyle, health care use, co-morbidities, and quality of life. The data included two cross-sectional time points in 2011 and 2017 and two 11 year longitudinal follow-ups during 2000-2011 and 2006-2017.

Results: The incidence and prevalence of nAMD were two times higher in women than in men. The annual prevalence of nAMD increased from 0.51% to 0.70% and from 0.22% to 0.46% in treated nAMD between 2011 and 2017. Treated nAMD patients had an average of 4 intravitreal injections per treatment year. nAMD patients showed significantly poorer distance and near VA than persons without any AMD in 2011 and 2017 (p < 0.001). However, near VA was significantly better in 2017 than in 2011 among nAMD patients (p = 0.036). The duration of nAMD showed weak negative correlation with distance and near VA. After adjusting for age and sex, nAMD patients showed significantly higher univariable odds ratios for lower distance VA, low consumption of vegetables, living in central Finland, a higher number of hospitalisations per year, and older age compared with persons without any AMD.

Conclusion: Since nAMD is an increasing burden for public health with gender discrepancy and a detrimental impact on vision, we should better find patients who have a high risk of developing nAMD and try to optimise their preventive intervention. Once nAMD is developed, we should understand treatment and follow-up demands at the personalised level. The nationwide register data help us in those challenges.

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来源期刊
Acta Ophthalmologica
Acta Ophthalmologica 医学-眼科学
CiteScore
7.60
自引率
5.90%
发文量
433
审稿时长
6 months
期刊介绍: Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.
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