姜黄素偶联ph响应木质素纳米颗粒的构建：稳定性、抗氧化活性和生物相容性。

IF 7.7 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2025-01-19 DOI:10.1016/j.ijbiomac.2025.140036

Huanli Gao, Farzad Seidi, Yuqun Cai, Ziwei Sun, Huiyang Bian, Hongqi Dai, Tingting Xu

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引用次数: 0

摘要

姜黄素具有显著的抗氧化作用，但稳定性差，生物相容性低，限制了其在治疗领域的应用。为了克服姜黄素的这些局限性，本研究通过酯化反应将姜黄素接枝到木质素上，制备出纳米颗粒。结果表明，姜黄素光热稳定性得到有效改善。此外，细胞毒性实验表明，li - cur纳米颗粒可以显著改善姜黄素的生物相容性。由缀合物形成的酯键也有助于li - cur纳米颗粒在受刺激的炎症组织中具有ph敏感性并释放姜黄素。最后，通过减少促炎因子，li - cur纳米颗粒可以有效清除活性氧（ROS）。除了缓解氧化应激外，li - cur纳米颗粒有望作为载体平台用于治疗许多其他炎症性疾病。

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Construction of curcumin-conjugated pH-responsive lignin-based nanoparticles for alleviating oxidative stress: Stability, antioxidant activity and biocompatibility

Curcumin has a great effect on alleviating oxidative stress, but its poor stability and low biocompatibility limit its application in therapeutic field. In order to overcome these limitations of curcumin, in this study, curcumin was grafted to lignin by esterification, and then prepared into nanoparticles. The results showed that the photothermal stability of curcumin was effectively improved. Moreover, cytotoxicity test showed that Lig-Cur nanoparticles can significantly improve the biocompatibility of curcumin. The ester bonds formed from conjugate also help Lig-Cur nanoparticles have pH-sensitivity in stimulated inflammatory tissue and release curcumin. Finally, by reducing proinflammatory factors, Lig-Cur nanoparticles could effectively scavenge reactive oxygen species (ROS). In addition to alleviating oxidative stress, Lig-Cur nanoparticles were expected to be used as a carrier platform for the treatment of many other inflammatory diseases.

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来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.