Haeun Kwon, Jieun Choi, Chanoong Lim, Junseong Kim, Asila Osman, Yongseok Jho, Dong Soo Hwang, Dong Woog Lee
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Strong Hydrophobic Interaction of High Molecular Weight Chitosan in Aqueous Solution.
Chitosan is a versatile bioactive polysaccharide in various industries, such as pharmaceuticals and environmental applications, owing to its abundance, biodegradability, biocompatibility, and antibacterial properties. To effectively harness its potential for various purposes, it is crucial to understand the mechanisms of its interaction in water. This study investigates the interactions between high molecular weight (HMW, >150 kDa) chitosan and four different functionalized self-assembled monolayers (SAMs) at three different pHs (3.0, 6.5, and 8.5) using a surface forces apparatus (SFA). We report that HMW chitosan exhibits the strongest adhesion to methyl-terminated SAM (CH3-SAM) at all pHs, showing potential for strong hydrophobic interactions against other molecules containing hydrophobic moieties. Noting that hydrogen bonding has been considered the dominating interaction mechanism of chitosan, the consequence of this study provides valuable insights into its applications in developing chitosan-based eco-friendly materials.
期刊介绍：
Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine.
Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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