Zhenyue Fu, Yajiao Wang, Lu Zhao, Yumeng Li, Qingqiao Song
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Seeking optimal non-pharmacological interventions for sarcopenia: a systematic review and network meta-analysis
Background
With the acceleration of aging, sarcopenia has become a reality of concern today. This study aimed to evaluate the efficacy of various non-pharmacologic interventions and find the optimal interventions for sarcopenia.
Methods
PubMed, Medline OVID, EMBASE, Scopus, and Cochrane were searched from 1 January 2000 to 25 October 2023, with language restrictions to English. We analyzed the data through the Bayesian network meta-analysis.
Results
Based on the inclusion and exclusion criteria defined by the PICOS principles, we identified 47 eligible clinical trials engaging 4889 individuals (including treatment group = 2835, control group = 2054). The results showed that resistance exercise (low-moderate load) significantly increased muscle mass (skeletal muscle mass and lean body mass) and that exercise plus nutrition improved physical activity indices (handgrip strength, gait speed, TUG test, chair standing).
Conclusion
Resistance exercise (low-moderate load), exercise plus nutrition, and nutritional supplementation (fatty acids, etc.) may be protective against sarcopenia.
期刊介绍：
Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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