Juan Wu, Mingming Yang, Deying Leng, Qiuping Hu, Yanxiu Yao, Huaming Sun and Ziwei Gao
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In situ generation and conversion of a half-zirconocene catalyst for the synthesis of N-acylpyrazoles†
Pyrazoles are an important class of five-membered nitrogen heterocyclic compounds that have been widely used in agriculture and medicine. Exploring their synthesis methods under mild conditions has always been a hot research topic. Herein, a new strategy was developed to enhance the activity of a zirconium metal centre for the synthesis of N-acylpyrazole derivatives using Cp2ZrCl2 as a pre-catalyst. Cp2ZrCl2 was activated in situ within the catalytic system through cyclopentadienyl ring dissociation, leading to the formation of an activated species, [CpZrCl(acac)2]. The new approach demonstrates broad substrate scope under mild reaction conditions, leading to formation of (3,5-dimethyl-1H-pyrazol-1-yl)(phenyl)methanones with yields of up to 97%.
期刊介绍:
An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.