合成n -酰基吡唑的半锆新世催化剂的原位生成和转化

IF 4.6 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
RSC Advances Pub Date : 2025-01-20 DOI:10.1039/D4RA08083A
Juan Wu, Mingming Yang, Deying Leng, Qiuping Hu, Yanxiu Yao, Huaming Sun and Ziwei Gao
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引用次数: 0

摘要

吡唑是一类重要的五元氮杂环化合物,在农业和医学上有着广泛的应用。探索其在温和条件下的合成方法一直是研究的热点。本文研究了以Cp2ZrCl2为预催化剂,提高金属锆中心活性的新策略,用于合成n -酰基吡唑衍生物。Cp2ZrCl2在催化体系内通过环戊二烯环解离原位活化,形成活性物质[CpZrCl(acac)2]。新方法表明,在温和的反应条件下,底物范围广,可生成(3,5-二甲基- 1h -吡唑-1-基)(苯基)甲烷,产率高达97%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

In situ generation and conversion of a half-zirconocene catalyst for the synthesis of N-acylpyrazoles†

In situ generation and conversion of a half-zirconocene catalyst for the synthesis of N-acylpyrazoles†

Pyrazoles are an important class of five-membered nitrogen heterocyclic compounds that have been widely used in agriculture and medicine. Exploring their synthesis methods under mild conditions has always been a hot research topic. Herein, a new strategy was developed to enhance the activity of a zirconium metal centre for the synthesis of N-acylpyrazole derivatives using Cp2ZrCl2 as a pre-catalyst. Cp2ZrCl2 was activated in situ within the catalytic system through cyclopentadienyl ring dissociation, leading to the formation of an activated species, [CpZrCl(acac)2]. The new approach demonstrates broad substrate scope under mild reaction conditions, leading to formation of (3,5-dimethyl-1H-pyrazol-1-yl)(phenyl)methanones with yields of up to 97%.

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来源期刊
RSC Advances
RSC Advances chemical sciences-
CiteScore
7.50
自引率
2.60%
发文量
3116
审稿时长
1.6 months
期刊介绍: An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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