Chen Liu , Yuting Jiang , Xingda Mu , Xuling Chang , Ye Zhang , Xiaoxiao He , Xiaojuan Zhu , Wenbo Sun , Lehui Lu
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Bionic synapses for real-time epileptic seizure control
Real-time optogenetic devices that can intelligently react to abnormal changes in the electrophysiological signals of epilepsy patients are crucial for timely seizure control. Inspired by electrical synapses, we report a bionic synapse built with entirely transparent ionic conductors. This system forms a soft, flexible network that allows free ionic movement, mimicking natural synaptic behavior. The bionic conductive technology is demonstrated in the application for brain signal recording-an emotion detection sensor. We also explore the potential of this technology for use in neural activity detections during optogenetic stimulation and emphasize its advantages in compromising optical recording. Furthermore, we have implemented this device for epileptic seizure control by real-time optogenetic modulation, which offers good potential for brain-machine interfaces in the monitoring and treatment of diseases. Our work highlights the advantages of transparent ionic conductors in combining electrophysiological recording and neural modulation, advancing both neurotechnology and bioelectronics.
期刊介绍:
Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.