PROTCROWN：解锁蛋白质-纳米颗粒相互作用潜力的蛋白质电晕数据的手动管理资源

IF 9.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-01-21 DOI:10.1021/acs.nanolett.4c05955

Yunyun Su, Xiuhao Fu, Leyi Wei, Zilong Zhang, Quan Zou, Feifei Cui

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引用次数: 0

摘要

“蛋白质冠”的出现是生物信息学和纳米技术中的一个关键概念，对于理解纳米药物传递和纳米粒子-生物实体相互作用至关重要。进入血液等生物液体后，纳米粒子（NPs，如纳米医学载体）迅速被蛋白质包裹，形成称为蛋白质冠的蛋白质界面层。深入研究蛋白质冠对于阐明NPs的生物学影响及其在医学领域内外的潜在应用至关重要。为了促进我们对NPs和生物系统之间复杂相互作用的理解，我们开发了PROTCROWN，这是首个蛋白质冠数据库。该资源系统地整理和组织与蛋白质冠状病毒有关的数据，促进该领域的先进分析和研究。它为研究人员提供了一个方便的数据查询平台，支持数据可视化和分析。我们的数据库procrown可在http://www.protcrown.cn访问。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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PROTCROWN: A Manually Curated Resource of Protein Corona Data for Unlocking the Potential of Protein–Nanoparticle Interactions

The emergence of the “Protein Corona” is a pivotal concept in bioinformatics and nanotechnology, crucial for understanding nanomedicine delivery and nanoparticle–biological entity interactions. After entering a biological fluid, such as blood, nanoparticles (NPs, such as nanomedical carriers) are quickly coated with proteins, forming a protein interface layer called the protein corona. An in-depth investigation into the protein corona is essential for elucidating the biological ramifications of NPs and their prospective applications within the medical field and beyond. To advance our understanding of the intricate interactions between NPs and biological systems, we have developed PROTCROWN, the inaugural protein corona database. This resource systematically curates and organizes data relevant to the protein corona, facilitating advanced analysis and research in the field. It provides a convenient data query platform for researchers and supports data visualization and analysis. Our database, PROTCROWN, is accessible at http://www.protcrown.cn.

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.