ELL3调节纺锤体组装以防止母体遗传的非整倍体和不孕症

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-01-22 DOI:10.1038/s41594-024-01475-4

Bernhard Magerl, Tommaso Cavazza

引用次数: 0

摘要

非整倍体是胚胎发育失败和流产的主要原因。一项新的研究发现了与流产有关的ELL3基因变异，并发现了ELL3在女性减数分裂中的新作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility

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ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility

Aneuploidy is a major cause of embryonic failure and miscarriage. A new study identifies genetic variants of ELL3 associated with miscarriage and discovers a novel role for ELL3 in female meiosis.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.