{"title":"ELL3调节纺锤体组装以防止母体遗传的非整倍体和不孕症","authors":"Bernhard Magerl, Tommaso Cavazza","doi":"10.1038/s41594-024-01475-4","DOIUrl":null,"url":null,"abstract":"Aneuploidy is a major cause of embryonic failure and miscarriage. A new study identifies genetic variants of ELL3 associated with miscarriage and discovers a novel role for ELL3 in female meiosis.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"129 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility\",\"authors\":\"Bernhard Magerl, Tommaso Cavazza\",\"doi\":\"10.1038/s41594-024-01475-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aneuploidy is a major cause of embryonic failure and miscarriage. A new study identifies genetic variants of ELL3 associated with miscarriage and discovers a novel role for ELL3 in female meiosis.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"129 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-024-01475-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-024-01475-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility
Aneuploidy is a major cause of embryonic failure and miscarriage. A new study identifies genetic variants of ELL3 associated with miscarriage and discovers a novel role for ELL3 in female meiosis.
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