以双 HATs 为介导的无催化剂 sp3 C-H 键官能化技术实现 Ynazoles 的区域选择性自由基氢烷基化

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-01-20 DOI:10.1002/adsc.202401372

Yu-Xin Wu, Xiang Chen, Bang-Yan Ou, Qian Yan, Si-Han Chen, Ya-Wen Zhao, Zhi-Wei Li, Han-Wen Liu, Jiang-Sheng Li

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引用次数: 0

摘要

用微量的二氧作为引发剂，通过sp3碳-氢键官能化，实现了ynazoles的直接氢烷基化，促进了线性N-β-乙烯基唑的高效合成。这种无试剂的方法消除了外源试剂的需要，并通过涉及双氢原子转移（HAT）过程的自由基链机制进行。其应用潜力通过实施规模操作得到了体现。

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Dual HATs-mediated Catalyst-free sp3 C-H Bond Functionalization for Regioselective Radical Hydroalkylation of Ynazoles

Direct hydroalkylation of ynazoles, facilitating the efficient synthesis of linear N-β-vinylazoles, is accomplished through the functionalization of sp3 C-H bonds using trace amounts of dioxygen as an initiator. This reagent-free method eliminates the need for exogenous reagents and proceeds through a radical chain mechanism involving dual hydrogen atom transfer (HAT) processes. Its application potential is exemplified through the implementation of scale-up operations.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.