手性季铵盐促进不对称亲核加成的最新进展

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2025-01-20 DOI:10.1021/acscatal.4c06497

Xiaoqun Yang, Youlin Deng, Dan Ling, Tingting Li, Lingzhu Chen, Zhichao Jin

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引用次数: 0

摘要

手性季铵离子对有机催化已广泛应用于具有挑战性立体中心的手性分子的快速合成。特别是，许多不对称的亲核加成反应已被促进与此策略。本文系统地综述了近十年来手性季铵盐促进的不对称亲核加成反应。内容是根据参与这些催化转化的亲电试剂的类型来组织的。我们对这一高度活跃的研究领域的未来发展也提供了自己的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recent Progress in Chiral Quaternary Ammonium Salt-Promoted Asymmetric Nucleophilic Additions

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Recent Progress in Chiral Quaternary Ammonium Salt-Promoted Asymmetric Nucleophilic Additions

Chiral quaternary ammonium ion-pair organocatalysis has been widely used in the facile synthesis of chiral molecules with challenging stereocenters. Especially, numerous asymmetric nucleophilic addition reactions have been facilitated with this strategy. This review systematically summarizes the asymmetric nucleophilic additions promoted by chiral quaternary ammonium salts in the past decade. The content is organized according to the types of electrophiles involved in these catalytic transformations. Our own perspectives on future development within this highly active research field are also provided.

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.