妊娠期有机磷酸酯和邻苯二甲酸酯共同暴露对学龄前儿童胰岛素作用的性别和妊娠期特异性影响：来自马鞍山出生队列的研究结果

IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-02-01 DOI:10.1016/j.envint.2025.109287

Hong Gan , Mengjuan Lu , Juan Tong , Huijuan Li , Qiong Zhou , Feifei Han , Xiaorui Wang , Shuangqin Yan , Kun Huang , Qunan Wang , Xiaoyan Wu , Beibei Zhu , Hui Gao , Fangbiao Tao

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引用次数: 0

摘要

产前暴露于有机磷酸酯（OPEs）和邻苯二甲酸酯（PAEs）在孕妇中普遍存在。然而，关于产前共同暴露于OPEs和PAEs与儿童胰岛素功能之间关系的研究仍然有限。方法本研究利用马鞍山出生队列2246对母胎的数据，分析OPEs和PAEs共同暴露与胰岛素作用之间的关系。从产妇尿液中反复检测磷酸三（2-氯乙基）、六种OPE代谢物和七种PAE代谢物。胰岛素抵抗稳态模型评估（HOMA-IR）和胰岛素作用指数（IAI）作为结局指标。在调整潜在混杂因素后，使用广义估计方程评估重复暴露对胰岛素作用的影响，而通过贝叶斯核机回归和基于分位数的g计算评估混合效应。结果研究时儿童的平均年龄为5.33 岁。重复测量分析显示，产前暴露于MEP与HOMA-IR升高呈正相关(β, 0.027；95 % CI: 0.002, 0.053)，而IAI与MEP水平升高呈负相关(β, 0.025；95 % CI:−0.046,−0.004)和MEHHP暴露(β,−0.128；95 % ci:−0.218,−0.037)。混合暴露模型进一步表明，OPEs和PAEs的共同暴露与HOMA-IR呈正相关(β, 0.058；95 % CI: 0.001, 0.114)，与IAI呈负相关(β,−0.054；95 % CI:−0.097,−0.010)，在妊娠中期观察到更强的效果。值得注意的是，与男性相比，这种关联在女性儿童中更为明显。结论：本研究首次提供了流行病学证据，强调了产前共同暴露于OPEs和PAEs与儿童胰岛素作用之间的妊娠和性别特异性联系。

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Sex- and trimester-specific impact of gestational co-exposure to organophosphate esters and phthalates on insulin action among preschoolers: Findings from the Ma’anshan birth cohort

Introduction

Prenatal exposure to organophosphate esters (OPEs) and phthalic acid esters (PAEs) is ubiquitous among pregnant individuals. However, research exploring the relationship between prenatal co-exposure to OPEs and PAEs and childhood insulin function remains limited.

Methods

In this study, utilizing data from 2,246 maternal-fetal dyads in the Ma’anshan Birth Cohort, associations between co-exposure to OPEs and PAEs and insulin action were analyzed. Repeated measures of tris (2-chloroethyl) phosphate, six OPE metabolites, and seven PAE metabolites were collected from maternal urine. Homeostasis model assessment of insulin resistance (HOMA-IR) and the insulin action index (IAI) served as outcome measures. After adjusting for potential confounders, the effects of repeated exposure on insulin action were evaluated using generalized estimating equations, while mixture effects were assessed through BayesianKernel Machine Regression and Quantile-Based G-Computation.

Results

The average age of the children at the time of the study was 5.33 years. Repeated measures analysis revealed that prenatal exposure to MEP was positively associated with increased HOMA-IR (β, 0.027; 95 % CI: 0.002, 0.053), while IAI was inversely correlated with rising MEP levels (β, 0.025; 95 % CI: −0.046, −0.004) and MEHHP exposure (β, −0.128; 95 % CI: −0.218, −0.037). Mixed exposure modeling further indicated that co-exposure to OPEs and PAEs was positively linked to HOMA-IR (β, 0.058; 95 % CI: 0.001, 0.114) and negatively correlated with IAI (β, −0.054; 95 % CI: −0.097, −0.010), with stronger effects observed during the second trimester. Notably, the association was more pronounced in female children compared to males.

Conclusions

This study provides the first epidemiological evidence highlighting the pregnancy- and sex-specific links between prenatal co-exposure to OPEs and PAEs and childhood insulin action.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.