合成酚类抗氧化剂暴露和超重/肥胖对性激素水平改变的协同作用：血糖正常的中国农村人口

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution Pub Date : 2025-01-17 DOI:10.1016/j.envpol.2025.125713

Lulu Wang , Changsheng Huan , Dandan Wei , Wenqian Huo , Chongjian Wang , Zhenxing Mao , Tao Jing

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引用次数: 0

摘要

合成酚类抗氧化剂（SPAs）的广泛使用导致其无处不在，并可能通过影响激素水平破坏而导致多种不良健康结果。本研究旨在评估血糖正常的中国农村人群血浆中spa的暴露水平，探讨单一和混合污染物暴露与性激素的关系，并分析体重指数（BMI）在这些关系中的调节作用。对763例血糖正常的河南农村人群进行了横断面研究。利用一般线性模型、限制三次样条模型、基于分位数的g计算（qgcomp）和贝叶斯核机回归（BKMR）来评估spa暴露与性激素之间的单一、非线性和混合关系。进一步研究了spa和BMI对性激素的联合和加性相互作用。在血糖正常的中国农村人群的血浆样本中广泛检测到spa， spa与单次暴露时孕激素和雄激素水平的改变有显著的联系，并因性别和绝经状态而异，其中一些联系是非线性的。超重/肥胖加强了spa对雄激素和雌激素的影响。混合效应分析表明，在男性中，spa与孕酮的联合混合效应为正，而在男性和绝经后女性中，spa与17-羟孕酮、睾酮和雄烯二酮的联合混合效应为负。在两种混合分析中，AO44B25、AO425、BHA、BHT-OH和AO2246对整体混合效果的相对贡献都较高。本研究首次分析了中国农村人群血浆样本中的spa，并发现spa暴露与男性和绝经后女性孕激素和雄激素水平改变之间的显著相关性，为spa的内分泌干扰作用提供了流行病学证据，为探索环境污染引起的多种疾病的病因提供了研究基础。

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Synergistic effect of synthetic phenolic antioxidant exposure and overweight/obesity on altered sex hormone levels: Normoglycemic rural Chinese population

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Synergistic effect of synthetic phenolic antioxidant exposure and overweight/obesity on altered sex hormone levels: Normoglycemic rural Chinese population

The widespread use of synthetic phenolic antioxidants (SPAs) has led to their ubiquity and may contribute to multiple adverse health outcomes by affecting hormone level disruption. This study aimed to assess the exposure levels of SPAs in the plasma of the normoglycemic rural Chinese population, investigate the association of single and mixed pollutant exposures with sex hormones, and analyze the moderating role of body mass index (BMI) in these relationships. A cross-sectional study including 763 individuals with normal blood glucose from the Henan Rural cohort was conducted. General linear models, restricted cubic spline models, quantile-based g computation (qgcomp), and Bayesian kernel machine regression (BKMR) were utilized to evaluate single, nonlinear, and mixed relationships between SPAs exposure and sex hormones. The combined and additive interactions of SPAs and BMI on sex hormones were further examined. SPAs were widely detected in the plasma samples of the normoglycemic rural Chinese population, and SPAs were significantly linked to altered progestogen and androgen levels in single exposure and varied by gender and menopausal status, and some of these associations were non-linear. Being overweight/obesity strengthened the effect of SPAs on androgens and estrogens. Mixture effect analyses suggested a positive joint mixture effect of SPAs with progesterone in men, and a negative joint mixture effect of SPAs with 17-hydroxyprogesterone, testosterone, and androstenedione in both men and postmenopausal women. The relative contribution of AO44B25, AO425, BHA, BHT-OH, and AO2246 to the overall mixing effect was higher in both mixture analyses. This study is the first to profile SPAs in plasma samples from the Chinese rural population and to identify significant associations between SPAs exposure and altered progestogen and androgen levels in men and postmenopausal women, providing epidemiological evidence for the endocrine-disrupting effects of SPAs and research basis for exploring the etiology of multiple diseases caused by environmental pollution.

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来源期刊

Environmental Pollution 环境科学-环境科学

CiteScore

16.00

自引率

6.70%

发文量

2082

审稿时长

2.9 months

期刊介绍： Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.