免疫的建筑师：树突状细胞如何在癌症中塑造CD8 + T细胞的命运

IF 17.6 1区医学 Q1 IMMUNOLOGY

Science Immunology Pub Date : 2025-01-17 DOI:10.1126/sciimmunol.adf4726

Vidit Bhandarkar, Teresa Dinter, Stefani Spranger

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引用次数: 0

摘要

对癌症的免疫反应主要是由T细胞衰竭和功能障碍。最近的进展强调了早期启动相互作用在建立T细胞命运中的关键作用。在这篇综述中，我们探讨了树突状细胞（DC）信号在癌症中指定CD8 + T细胞命运的重要性，借鉴了急性和慢性病毒感染模型的见解。我们强调了dc在淋巴结和肿瘤中维持干细胞样CD8 + T细胞的作用，这对于持久的抗肿瘤免疫反应至关重要。了解CD8 + T细胞命运是如何决定的，将有助于合理设计免疫疗法，特别是治疗性癌症疫苗，它可以调节DC-T细胞相互作用，产生有益的CD8 + T细胞命运。

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Architects of immunity: How dendritic cells shape CD8 + T cell fate in cancer

Immune responses against cancer are dominated by T cell exhaustion and dysfunction. Recent advances have underscored the critical role of early priming interactions in establishing T cell fates. In this review, we explore the importance of dendritic cell (DC) signals in specifying CD8 + T cell fates in cancer, drawing on insights from acute and chronic viral infection models. We highlight the role of DCs in lymph nodes and tumors in maintaining stem-like CD8 + T cells, which are critical for durable antitumor immune responses. Understanding how CD8 + T cell fates are determined will enable the rational design of immunotherapies, particularly therapeutic cancer vaccines, that can modulate DC–T cell interactions to generate beneficial CD8 + T cell fates.

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来源期刊

Science Immunology Immunology and Microbiology-Immunology

CiteScore

32.90

自引率

2.00%

发文量

183

期刊介绍： Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.