体重和基于血液的恶病质标志物预测癌症免疫治疗患者的残疾、住院和更差的生存

IF 8.9 1区医学

Journal of Cachexia, Sarcopenia and Muscle Pub Date : 2025-01-16 DOI:10.1002/jcsm.13685

Steven D. Tran, Noah J. Forrest, Vijeeth Guggilla, Geovanni M. Perottino, Jodi L. Johnson, Jeffrey Sosman, Ishan Roy, Theresa L. Walunas

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引用次数: 0

摘要

癌症相关恶病质可抑制免疫检查点抑制剂（ICI）的治疗效果。除肺癌外，恶病质对ICI治疗的影响尚未在大型癌症患者队列中进行研究。我们研究了真实世界常规收集的临床恶病质标志物与癌症患者无残疾、无住院和总生存率之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Weight and Blood-Based Markers of Cachexia Predict Disability, Hospitalization and Worse Survival in Cancer Immunotherapy Patients

Cancer-associated cachexia can inhibit immune checkpoint inhibitor (ICI) therapy efficacy. Cachexia's effect on ICI therapy has not been studied in large cohorts of cancer patients aside from lung cancer. We studied associations between real-world routinely collected clinical cachexia markers and disability-free, hospitalization-free and overall survival of cancer patients.

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来源期刊

Journal of Cachexia, Sarcopenia and Muscle Medicine-Orthopedics and Sports Medicine

自引率

12.40%

发文量

期刊介绍： The Journal of Cachexia, Sarcopenia, and Muscle is a prestigious, peer-reviewed international publication committed to disseminating research and clinical insights pertaining to cachexia, sarcopenia, body composition, and the physiological and pathophysiological alterations occurring throughout the lifespan and in various illnesses across the spectrum of life sciences. This journal serves as a valuable resource for physicians, biochemists, biologists, dieticians, pharmacologists, and students alike.