酵母为癌症免疫治疗铺平了道路

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2025-01-16 DOI:10.1016/j.chembiol.2024.12.011

Dingjiacheng Jia, Shujie Chen

引用次数: 0

摘要

在这一期的Cell Chemical Biology上，Rebeck et al.1构建了一个系统，使酿酒酵母（Saccharomyces cerevisiae var. boulardii, Sb）分泌免疫检查点抑制剂，减少肠道肿瘤负荷。这种安全有效的工程酵母传递平台显示了增强生物制剂功效的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Yeast paves the way for cancer immunotherapy

In this issue of Cell Chemical Biology, Rebeck et al.¹ construct a system that enables Saccharomyces cerevisiae var. boulardii (Sb) to secrete immune checkpoint inhibitors, reducing intestinal tumor load. This safe and effective delivery platform using engineered yeast demonstrates potential for enhancing the efficacy of biologics.

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.