职业性接触军用喷气燃料对健康的影响：流行病学文献的系统综述

IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-02-01 DOI:10.1016/j.envint.2025.109278

Terra D. Vincent-Hall , Justin G. Bergeron , Sorina E. Eftim , Alexander J. Lindahl , Kate R. Weinberger , Cary E. Haver , Samantha J. Snow

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引用次数: 0

摘要

在涉及飞机的职业环境中，喷气燃料是一种常见的化学物质。喷气燃料是芳烃和脂肪烃以及非烃性能添加剂的非均相混合物。航空燃料的若干成分与不利的健康后果有关。“上士希斯·罗宾逊履行我们的承诺，解决2022年全面毒素法案”要求美国退伍军人事务部（VA）向国会提交一份关于军队使用的喷气燃料对健康影响的报告。目的本调查采用可靠且可重复的系统评价方法，评估军事和非军事环境中职业接触航空燃料对健康影响的流行病学证据。方法检索截至2024年1月26日的2个科学数据库（PubMed和EBSCOhost）、17篇 Gy文献来源和5篇综述文章，检索相关的、初步流行病学研究。根据美国环境保护署（EPA）综合风险信息系统（IRIS）评估框架进行系统评价和证据合成，评估偏倚风险和证据强度。结果共有28项研究符合纳入标准，其中18项研究来自军事环境，10项研究来自非军事职业环境。研究确定，有少量证据表明喷气燃料暴露与神经系统、认知和行为、呼吸系统和癌症预后之间存在关联。对于所有其他健康结果类别，航空燃料对人类影响的现有证据被认为是不确定的。据我们所知，这是对职业性航空燃油暴露对健康影响的流行病学证据的首次系统综述。多种健康结局的可用数据很少，而且大多数研究往往质量较低。未来的工作将包括扩大审查的范围，以整合毒理学和机制证据。

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Health effects of occupational exposure to jet fuels used in the military: A systematic review of the epidemiologic literature

Background

Jet fuels are a common chemical exposure in occupational settings involving aircraft. Jet fuels are heterogeneous mixtures of aromatic and aliphatic hydrocarbons, as well as non-hydrocarbon performance additives. Several components of jet fuels have been linked to adverse health outcomes. The “Sergeant First Class Heath Robinson Honoring Our Promise to Address Comprehensive Toxins Act of 2022” required the U.S. Department of Veterans Affairs (VA) to develop a report to Congress on the health effects of jet fuels used in the military.

Objectives

This investigation assessed the epidemiologic evidence of the health effects associated with occupational exposure to jet fuels in military and non-military settings using robust and reproducible systematic review methods.

Methods

Two scientific databases (PubMed and EBSCOhost), 17 gray literature sources and five review articles were searched for relevant, primary epidemiologic studies through May, 2024. Risk of bias and strength of evidence were evaluated according to the U.S. Environmental Protection Agency’s (EPA) Integrated Risk Information System (IRIS) assessment framework for systematic reviews and evidence synthesis.

Results

Twenty-eight studies met the inclusion criteria, including 18 studies in military settings and 10 studies in non-military occupational settings. It was determined that there was slight evidence of associations between jet fuel exposure and neurologic, cognitive and behavioral, respiratory, and cancer outcomes. For all other health outcome categories, the available evidence of jet fuels effect on humans was considered indeterminate.

Discussion

To our knowledge, this is the first systematic review of epidemiologic evidence on the health effects of occupational jet fuel exposure. Available data were sparse for multiple health outcomes, and most studies tended to be of lower quality. Future work will include expanding the scope of the review to integrate toxicological and mechanistic evidence.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.