降低NEPC的热度

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2025-01-16 DOI:10.1038/s41585-025-00995-y

Louise Lloyd

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引用次数: 0

摘要

热休克蛋白60 （HSP60）是线粒体未折叠蛋白反应的主要伴侣，可能是神经内分泌前列腺癌（NEPC）的潜在治疗靶点。临床前证据表明，抑制HSP60可减少NEPC在体内的生长。在TRAMP小鼠模型中，来自肿瘤样本的线粒体部分的氧化磷酸化复合物活性不正常。使用HSP60作为替代读数来评估线粒体未展开蛋白反应，在几种侵袭性前列腺癌模型和患者样本数据集中增加。

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Turning down the heat in NEPC

Heat shock protein 60 (HSP60), the main chaperone of the mitochondrial unfolded protein response, could be a potential therapeutic target in neuroendocrine prostate cancer (NEPC). Preclinical evidence shows that HSP60 inhibition reduces NEPC growth in vivo.

In the TRAMP mouse model, oxidative phosphorylation complex activity was dysfunctional in mitochondrial fractions from tumour samples. The mitochondrial unfolded protein response, assessed using HSP60 as a surrogate readout, was increased in several models of aggressive prostate cancer and patient sample datasets.

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.