吲哚菁绿荧光成像预测活体供肝移植胆道并发症的可行性:一项初步研究。

IF 1.1 Q4 GASTROENTEROLOGY & HEPATOLOGY
Jaewon Lee, YoungRok Choi, Nam-Joon Yi, Jae-Yoon Kim, Su Young Hong, Jeong-Moo Lee, Suk Kyun Hong, Kwang-Woong Lee, Kyung-Suk Suh
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引用次数: 0

摘要

背景/目的:肝移植(LT)是目前治疗肝硬化或肝细胞癌患者的重要救命疗法。尽管肝移植有很多好处,但胆道并发症(BCs)仍然是术后发病率的主要原因。本研究利用近红外吲哚青绿(ICG)成像评估总胆管(CBD)的荧光强度(FI),并研究其与 LT 术后三个月内胆道并发症发生率的关系:这项调查分析了九名活体LT(LDLT)受者的数据,这些受者在胆管吻合术前注射了0.05 mg/kg的ICG。使用 ICG 相机记录了三分钟的 CBD 实时灌注情况,并使用 Image J(美国国立卫生研究院)对 FI 进行了量化。评估的主要参数包括 F max、F1/2 max、T1/2 max 和斜率(F max/T max),以评估荧光反应:9名患者中有2名出现了BC。这两名患者的最大 T1/2 值最长,而斜率值较低,这表明最大 T1/2 值延长、斜率降低与术后 BCs 的发生之间存在潜在关系:研究表明,ICG 荧光成像可作为评估 LDLT 患者胆管灌注的有效工具。虽然数据表明最大 T1/2 延长和斜率降低可能与 BCs 风险增加相关,但仍需通过更大规模的研究进一步验证 ICG 荧光成像在这种情况下的预测价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Feasibility of indocyanine green fluorescence imaging to predict biliary complications in living donor liver transplantation: A pilot study.

Backgrounds/aims: Liver transplantation (LT) is now a critical, life-saving treatment for patients with liver cirrhosis or hepatocellular carcinoma. Despite its significant benefits, biliary complications (BCs) continue to be a major cause of postoperative morbidity. This study evaluates the fluorescence intensity (FI) of the common bile duct (CBD) utilizing near-infrared indocyanine green (ICG) imaging, and examines its association with the incidence of BCs within three months post-LT.

Methods: This investigation analyzed data from nine living donor LT (LDLT) recipients who were administered 0.05 mg/kg of ICG prior to bile duct anastomosis. Real-time perfusion of the CBD was recorded for three minutes using an ICG camera, and FI was quantified using Image J (National Institutes of Health). Key parameters assessed included F max, F1/2 max, T1/2 max, and the slope (F max/T max) to evaluate the fluorescence response.

Results: BCs occurred in two out of nine patients. These two patients exhibited the longest T1/2 max values, which were linked with lower slope values, implicating a potential relationship between extended T1/2 max, reduced slope, and the occurrence of postoperative BCs.

Conclusions: The study indicates that ICG fluorescence imaging may serve as an effective tool for assessing bile duct perfusion in LDLT patients. While the data suggest that an extended T1/2 max and lower slope may correlate with an increased risk of BCs, further validation through larger studies is required to confirm the predictive value of ICG fluorescence imaging in this setting.

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