免疫球蛋白蛋黄和氧化铈为基础的纤维聚乳酸/明胶敷料使皮肤再生的感染性伤口模型。

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2025-02-01 DOI:10.1016/j.mtbio.2024.101408

Xinyuan Zhao , Changwen Weng , Hao Feng , Muhammad Shafiq , Xinyi Wang , Lei Liu , Lu Han , Mohamed EL-Newehy , Meera Moydeen Abdulhameed , Zhengchao Yuan , Xiumei Mo , Yanbiao Wang

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引用次数: 0

摘要

细菌感染和氧化伤口微环境延迟皮肤修复，需要智能伤口敷料实现无疤痕伤口愈合。卵黄免疫球蛋白（IgY）对抗微生物耐药病原体具有潜在的免疫治疗潜力，而氧化铈纳米颗粒（CeO2 NPs）可以清除超氧化物歧化酶（SOD）和炎症。本研究的总体目标是将IgY和CeO2 NPs掺入聚（l -丙交酯-羟基乙酸酯）/明胶（PLGA/Gel）基敷料（P/G@IYCe）中，用于感染皮肤修复。P/G@IYCe具有良好的生物相容性，对金黄色葡萄球菌（S. aureus）和大肠杆菌（E.coil）具有明显的体外抑菌作用。大鼠皮下膜植入表现出细胞相容性。在金黄色葡萄球菌感染的全层切除缺损中，移植2周后，P/G@IYCe敷料在疤痕组织形成、炎症消退和活性氧清除方面的效果明显优于其他组。综上所述，IgY和CeO2的双重输送可能会实现智能伤口敷料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The immunoglobulin of yolk and cerium oxide-based fibrous poly(L-lactide-co-glycolide)/gelatin dressings enable skin regeneration in an infectious wound model

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The immunoglobulin of yolk and cerium oxide-based fibrous poly(L-lactide-co-glycolide)/gelatin dressings enable skin regeneration in an infectious wound model

The bacterial infection and oxidative wound microenvironment delay skin repair and necessitate intelligent wound dressings to enable scarless wound healing. The immunoglobulin of yolk (IgY) exhibits immunotherapeutic potential for the potential treatment of antimicrobial-resistant pathogens, while cerium oxide nanoparticles (CeO₂ NPs) could scavenge superoxide dismutase (SOD) and inflammation. The overarching objective of this study was to incorporate IgY and CeO₂ NPs into poly(L-lactide-co-glycolide)/gelatin (PLGA/Gel)-based dressings (P/G@IYCe) for infected skin repair. The P/G@IYCe manifested good biocompatibility as well as showed significant antibacterial effect against Staphylococcus aureus (S. aureus) and Escherichia coli (E.coil) in vitro. Subcutaneous implantation of membranes in rats exhibited cytocompatibility. Transplantation of membranes in S. aureus-infected full-thickness excisional defects manifested significant beneficial effect of P/G@IYCe dressings than that of the other groups in terms of the scar tissue formation, inflammation resolution, and scavenging of reactive oxygen species (ROS) at 2 weeks post-transplantation. Taken together, the dual delivery of IgY and CeO₂ may enable intelligent wound dressings.

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).