脑卒中后单侧空间忽视（USN）患者低频波动分数幅值（fALFF）与忽视严重程度的关系：一项功能近红外光谱研究

IF 2 Q3 NEUROSCIENCES

IBRO Neuroscience Reports Pub Date : 2024-12-12 DOI:10.1016/j.ibneur.2024.12.005

Shanshan Shi , Jiaxing Meng , Xiaohua Wu , Jie Wang , Hujun Wang , Pengfei Li , Shuyan Qie

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引用次数: 0

摘要

目的：右脑卒中后的单侧空间忽视（USN）比左脑卒中更明显、更严重、更持久。然而，USN的病理生理机制在很大程度上仍然未知。本研究旨在利用静息状态功能近红外光谱（fNIRS）技术研究脑卒中后USN患者右半球低频波动分数幅值（fALFF）与忽视严重程度的关系。这可能为USN患者脑区自发神经活动的病理生理微妙变化提供新的理论见解。方法：选取脑卒中后USN患者17例（USN组），对照组24例（对照组）。使用22通道fNIRS系统测试所有受试者休息时右半球血流动力学信号。使用NIRS-KIT工具箱对数据进行预处理和分析。USN组患者采用常规行为注意力不集中测试（BIT-C）和Catherine Bergego量表（CBS）进行评估。比较两组间通道间的fALFF值的差异，USN组中显示显著差异的通道的fALFF值与评估USN严重程度的量表得分相关。结果：(1)USN组与对照组在特定通道上的fALFF值存在显著差异，其中USN组CH6和CH11通道的fALFF值明显低于对照组（p ）结论：USN患者左侧忽视症状的严重程度可能与右侧背外侧前额叶皮质区代偿神经功能活动有关。

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The relationship between fractional amplitude of low-frequency fluctuations (fALFF) and the severity of neglect in patients with unilateral spatial neglect (USN) after stroke: A functional near-infrared spectroscopy study

Objective

Unilateral spatial neglect (USN) following right hemisphere stroke is more pronounced, severe, and persistent than in the left hemisphere. However, the pathophysiological mechanisms underlying USN remain largely unknown. This study aims to investigate the relationship between the fractional amplitude of low-frequency fluctuations (fALFF) in the right hemisphere of patients with post-stroke USN and the severity of neglect using resting-state functional near-infrared spectroscopy (fNIRS) technology. This could provide new theoretical insights into the subtle changes in the pathophysiology of spontaneous neural activity in brain regions of patients with USN.

Methods

Seventeen patients with post-stroke USN (USN group) and twenty-four control subjects (control group) were selected. A 22-channel fNIRS system was used to test the hemodynamic signals of the right hemisphere at rest for all subjects. Data preprocessing and analysis were performed using the NIRS-KIT toolbox. Patients in the USN group were assessed using the Behavioral Inattention Test-Conventional (BIT-C) and the Catherine Bergego Scale (CBS). Differences in fALFF values across channels between the two groups were compared, and the fALFF values from channels showing significant differences in the USN group were correlated with scores on scales evaluating the severity of USN.

Results

(1) Significant differences in fALFF values were observed between the USN and control groups in specific channels, with channels CH6 and CH11 showing significantly lower fALFF values in the USN group compared to the control group (p < 0.05), while channels CH12, CH16, and CH21 exhibited significantly higher fALFF values in the USN group (p < 0.05). (2) In patients with USN, fALFF values in CH12 were significantly negatively correlated with BIT-C scores (r = -0.4966, p = 0.0443), and fALFF values in CH21 were also significantly negatively correlated with BIT-C scores (r = -0.5270, p = 0.0318). (3) Only the fALFF values in CH21 were significantly positively correlated with CBS scores in patients with USN (r = 0.5512, p = 0.0236).

Conclusions

The severity of symptoms of neglect towards the left side in patients with USN may be related to compensatory neural functional activity in the right dorsolateral prefrontal cortex area.

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