Danilo Rodrigues Honório, Ana Luiza da Silva Ribeiro, Tamires Lorrayne Morais da Silva, Daniela Cristina Machado Tameirão, Luciano Rezende Vilela, Fernando Felicioni
{"title":"产前人类大脑发育不能幸免于IUGR：一项系统综述。","authors":"Danilo Rodrigues Honório, Ana Luiza da Silva Ribeiro, Tamires Lorrayne Morais da Silva, Daniela Cristina Machado Tameirão, Luciano Rezende Vilela, Fernando Felicioni","doi":"10.1016/j.earlhumdev.2025.106199","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Intrauterine growth restriction (IUGR) is a severe condition in which the fetus fails to reach its genetically predetermined growth potential, impairing prenatal development and predisposing individuals to postnatal consequences that may persist into adulthood. Although fetal mechanisms such as the brain-sparing effect have been proposed to protect the brain against IUGR-related deficits, the extent of this protection remains unclear.</p><p><strong>Objective: </strong>To conduct a systematic review that demonstrates prenatal morphofunctional abnormalities in the brain of individuals with IUGR.</p><p><strong>Methods: </strong>A comprehensive literature search was performed in the MEDLINE/PubMed database using keywords and Boolean operators: IUGR AND newborn AND nervous system NOT review. Inclusion criteria used: free and full-text availability, publication date from January 1, 2013, to July 31, 2024, newborns (birth to 1 month), and both sexes. Exclusion criteria included studies of older infants, lack of focus on the central nervous system, multiple pregnancies, concurrent pathologies with IUGR, use of animal models, and review articles. The review protocol is registered with PROSPERO (ID: CRD42024542500).</p><p><strong>Results: </strong>Seventeen studies were identified, totaling 2085 individuals. Of these, 1203 had some form of IUGR (early- or late-onset, symmetrical or asymmetrical, with or without circulatory centralization), whereas 882 were appropriate for gestational age (AGA) and served as controls. Across all studies, individuals with IUGR showed biometric, morphological, and/or cerebral vascular abnormalities, even when biparietal diameter or head circumference measurements were similar to those of AGA individuals.</p><p><strong>Conclusion: </strong>Prenatal human brain development is not spared by IUGR.</p>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"201 ","pages":"106199"},"PeriodicalIF":2.2000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prenatal human brain development is not spared by IUGR: A systematic review.\",\"authors\":\"Danilo Rodrigues Honório, Ana Luiza da Silva Ribeiro, Tamires Lorrayne Morais da Silva, Daniela Cristina Machado Tameirão, Luciano Rezende Vilela, Fernando Felicioni\",\"doi\":\"10.1016/j.earlhumdev.2025.106199\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Intrauterine growth restriction (IUGR) is a severe condition in which the fetus fails to reach its genetically predetermined growth potential, impairing prenatal development and predisposing individuals to postnatal consequences that may persist into adulthood. Although fetal mechanisms such as the brain-sparing effect have been proposed to protect the brain against IUGR-related deficits, the extent of this protection remains unclear.</p><p><strong>Objective: </strong>To conduct a systematic review that demonstrates prenatal morphofunctional abnormalities in the brain of individuals with IUGR.</p><p><strong>Methods: </strong>A comprehensive literature search was performed in the MEDLINE/PubMed database using keywords and Boolean operators: IUGR AND newborn AND nervous system NOT review. Inclusion criteria used: free and full-text availability, publication date from January 1, 2013, to July 31, 2024, newborns (birth to 1 month), and both sexes. Exclusion criteria included studies of older infants, lack of focus on the central nervous system, multiple pregnancies, concurrent pathologies with IUGR, use of animal models, and review articles. The review protocol is registered with PROSPERO (ID: CRD42024542500).</p><p><strong>Results: </strong>Seventeen studies were identified, totaling 2085 individuals. Of these, 1203 had some form of IUGR (early- or late-onset, symmetrical or asymmetrical, with or without circulatory centralization), whereas 882 were appropriate for gestational age (AGA) and served as controls. Across all studies, individuals with IUGR showed biometric, morphological, and/or cerebral vascular abnormalities, even when biparietal diameter or head circumference measurements were similar to those of AGA individuals.</p><p><strong>Conclusion: </strong>Prenatal human brain development is not spared by IUGR.</p>\",\"PeriodicalId\":11435,\"journal\":{\"name\":\"Early human development\",\"volume\":\"201 \",\"pages\":\"106199\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Early human development\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.earlhumdev.2025.106199\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Early human development","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.earlhumdev.2025.106199","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Prenatal human brain development is not spared by IUGR: A systematic review.
Background: Intrauterine growth restriction (IUGR) is a severe condition in which the fetus fails to reach its genetically predetermined growth potential, impairing prenatal development and predisposing individuals to postnatal consequences that may persist into adulthood. Although fetal mechanisms such as the brain-sparing effect have been proposed to protect the brain against IUGR-related deficits, the extent of this protection remains unclear.
Objective: To conduct a systematic review that demonstrates prenatal morphofunctional abnormalities in the brain of individuals with IUGR.
Methods: A comprehensive literature search was performed in the MEDLINE/PubMed database using keywords and Boolean operators: IUGR AND newborn AND nervous system NOT review. Inclusion criteria used: free and full-text availability, publication date from January 1, 2013, to July 31, 2024, newborns (birth to 1 month), and both sexes. Exclusion criteria included studies of older infants, lack of focus on the central nervous system, multiple pregnancies, concurrent pathologies with IUGR, use of animal models, and review articles. The review protocol is registered with PROSPERO (ID: CRD42024542500).
Results: Seventeen studies were identified, totaling 2085 individuals. Of these, 1203 had some form of IUGR (early- or late-onset, symmetrical or asymmetrical, with or without circulatory centralization), whereas 882 were appropriate for gestational age (AGA) and served as controls. Across all studies, individuals with IUGR showed biometric, morphological, and/or cerebral vascular abnormalities, even when biparietal diameter or head circumference measurements were similar to those of AGA individuals.
Conclusion: Prenatal human brain development is not spared by IUGR.
期刊介绍：
Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival.
The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas:
Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.
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