{"title":"低浓度二氧化氯气体杀菌萎缩芽孢杆菌和嗜热硬脂地杆菌孢子的新方法。","authors":"Koushirou Sogawa, Hideaki Tagishi, Hideaki Kato, Takashi Shibata, Takanori Miura","doi":"10.4265/jmc.29.4_153","DOIUrl":null,"url":null,"abstract":"<p><p>Chlorine dioxide (ClO<sub>2</sub>) is a powerful disinfectant widely regarded as a safe and effective hygienic agent in pharmaceutical plants and other manufacturing facilities that require sterility. However, the efficacy of low concentrations of ClO<sub>2</sub> gas on sterilizing spore-forming bacteria remains uncertain. In this study, we investigated the optimal conditions for disinfection of spore-forming bacteria with low concentrations of ClO<sub>2</sub> gas using biological indicators. The results showed that 0.05 ppmv (0.13 mg/m<sup>3</sup>) ClO<sub>2</sub> gas at 37±1℃, 86±2%RH sterilized Bacillus atrophaeus in 14 d and Geobacillus stearothermophilus in 28 d (>6 log<sub>10</sub> reductions）. Based on these results, we propose that low concentrations of ClO<sub>2</sub> gas are useful for controlling contamination by spore-forming bacteria in aseptic facilities.</p>","PeriodicalId":73831,"journal":{"name":"Journal of microorganism control","volume":"29 4","pages":"153-156"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Novel sterilization method of Bacillus atrophaeus and Geobacillus stearothermophilus spores by low concentration chlorine dioxide gas.\",\"authors\":\"Koushirou Sogawa, Hideaki Tagishi, Hideaki Kato, Takashi Shibata, Takanori Miura\",\"doi\":\"10.4265/jmc.29.4_153\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Chlorine dioxide (ClO<sub>2</sub>) is a powerful disinfectant widely regarded as a safe and effective hygienic agent in pharmaceutical plants and other manufacturing facilities that require sterility. However, the efficacy of low concentrations of ClO<sub>2</sub> gas on sterilizing spore-forming bacteria remains uncertain. In this study, we investigated the optimal conditions for disinfection of spore-forming bacteria with low concentrations of ClO<sub>2</sub> gas using biological indicators. The results showed that 0.05 ppmv (0.13 mg/m<sup>3</sup>) ClO<sub>2</sub> gas at 37±1℃, 86±2%RH sterilized Bacillus atrophaeus in 14 d and Geobacillus stearothermophilus in 28 d (>6 log<sub>10</sub> reductions）. Based on these results, we propose that low concentrations of ClO<sub>2</sub> gas are useful for controlling contamination by spore-forming bacteria in aseptic facilities.</p>\",\"PeriodicalId\":73831,\"journal\":{\"name\":\"Journal of microorganism control\",\"volume\":\"29 4\",\"pages\":\"153-156\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of microorganism control\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4265/jmc.29.4_153\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of microorganism control","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4265/jmc.29.4_153","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Novel sterilization method of Bacillus atrophaeus and Geobacillus stearothermophilus spores by low concentration chlorine dioxide gas.
Chlorine dioxide (ClO2) is a powerful disinfectant widely regarded as a safe and effective hygienic agent in pharmaceutical plants and other manufacturing facilities that require sterility. However, the efficacy of low concentrations of ClO2 gas on sterilizing spore-forming bacteria remains uncertain. In this study, we investigated the optimal conditions for disinfection of spore-forming bacteria with low concentrations of ClO2 gas using biological indicators. The results showed that 0.05 ppmv (0.13 mg/m3) ClO2 gas at 37±1℃, 86±2%RH sterilized Bacillus atrophaeus in 14 d and Geobacillus stearothermophilus in 28 d (>6 log10 reductions）. Based on these results, we propose that low concentrations of ClO2 gas are useful for controlling contamination by spore-forming bacteria in aseptic facilities.
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