[建味消石颗粒物理性质的确定及离散元模拟参数的标定]。

Q3 Pharmacology, Toxicology and Pharmaceutics
Zi-Qian Wang, Fan Wu, Zhi-Jian Zhong, Xiao-Rong Luo, Xin-Hao Wan, Jia-Li Liao, Qing Tao, Zhen-Feng Wu
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引用次数: 0

摘要

健胃消石颗粒作为健胃消石片的原料药,其离散元模型的构建方法和模拟参数设置尚不明确。模拟模型的准确性对颗粒间的动态响应特性有重要影响。因此,有必要对参数进行标定,以提高仿真参数的精度。以健胃消石颗粒的休止角为响应值,采用响应面法对离散元参数进行优化和标定。通过物理实验对健胃消石颗粒的物理性质进行了测定。基于Hertz-Mindlin - Johnson-Kendall-Roberts(JKR) V2模型和虚拟仿真方法,在EDEM软件中构建了休止角确定模型。采用图像分析和数值拟合的方法测量了静息角。采用Plackett-Burman实验筛选离散元模拟中有意义的初始参数。然后对重要参数进行最陡爬坡实验,确定最佳参数范围。在Box-Behnken实验的基础上,建立了显著性参数与休止角之间的二阶回归方程,以物理实验中的休止角为目标值37.64°。对回归方程进行了优化求解。显著性筛选实验表明,建味消石颗粒的颗粒-颗粒静摩擦系数、颗粒-颗粒滚动摩擦、颗粒-钢板滚动摩擦对模拟休止角影响显著。最优参数组合为0.330、0.222、0.229。该优化参数组合的模拟结果表明,模拟休止角与物理实验所得休止角无显著差异,相对误差为0.05%,进一步验证了建胃消石颗粒标定离散元参数的可靠性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Determination of physical properties and calibration of discrete element simulation parameters for Jianwei Xiaoshi Granules].

The construction method and simulation parameter settings for the discrete element model of Jianwei Xiaoshi Granules, as the primary material of Jianwei Xiaoshi Tablets, are not yet clear. The accuracy of the simulation model significantly influences the dynamic response characteristics between granules. Therefore, it is necessary to calibrate the parameters to improve the accuracy of the simulation parameters. Using the repose angle of Jianwei Xiaoshi Granules as the response value, the response surface methodology was employed to optimize and calibrate the discrete element parameters. Physical experiments were conducted to determine the physical properties of Jianwei Xiaoshi Granules. Based on the Hertz-Mindlin with Johnson-Kendall-Roberts(JKR) V2 model and virtual simulation methods, a repose angle determination model was constructed in EDEM software. The repose angle was measured using image analysis and numerical fitting methods. The Plackett-Burman experiment was used to screen the initial parameters for significance in the discrete element simulation. The significant parameters were then subjected to a steepest ascent experiment to determine the optimal parameter range. Furthermore, based on the Box-Behnken experiment, a second-order regression equation between significant parameters and repose angle was established, with the repose angle of 37.64° in the physical experiment as the target value. The regression equation was optimized and solved. The significance screening experiment revealed that the granule-granule static friction coefficient, granule-granule rolling friction, and granule-steel plate rolling friction of Jianwei Xiaoshi Granules significantly influenced the simulated repose angle. The optimal parameter combination was found to be 0.330, 0.222, and 0.229. The simulation results with this optimal parameter combination showed that there was no significant difference between the simulated repose angle and the repose angle obtained in the physical experiment, with a relative error of 0.05%, which further validated the reliability of the calibrated discrete element parameters for Jianwei Xiaoshi Granules.

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来源期刊
Zhongguo Zhongyao Zazhi
Zhongguo Zhongyao Zazhi Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.50
自引率
0.00%
发文量
581
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