[基于BMP和SIRT信号通路的中药治疗慢性肾脏疾病血管钙化的机制]。

Q3 Pharmacology, Toxicology and Pharmaceutics
Tian-Hao Sun, Wen Zhang, Jing Li, Yu-Xin Sun, Hong-Shuo Dong, Hong-Tao Yang
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引用次数: 0

摘要

血管钙化显著增加慢性肾脏疾病(CKD)患者心血管疾病的发病率和全因死亡率,严重影响其健康和寿命。然而,CKD血管钙化的机制仍然不完全清楚,可用的治疗药物有限。研究发现,血管平滑肌细胞(VSMCs)从收缩表型向成骨细胞样表型的转变是ckd相关血管钙化的关键步骤。随着钙化发病机制研究的深入,已经证明骨形态发生蛋白(BMP)和沉默信息调节因子(SIRT)信号通路可通过调控VSMCs的成骨转分化参与血管钙化过程。几百年来,中医在预防和治疗肾脏疾病方面积累了丰富的宝贵经验。现代研究表明,中医药以其多途径、多靶点、低毒性的特点,在防治ckd相关血管钙化、提高患者生活质量方面显示出一定优势。因此,在本研究中,我们将介绍中医在防治ckd相关血管钙化方面的最新研究进展,重点关注BMP和SIRT信号通路,旨在为临床中医诊治ckd相关血管钙化及相关基础研究提供思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Mechanism of traditional Chinese medicine in treating vascular calcification in chronic kidney disease based on BMP and SIRT signaling pathways].

Vascular calcification significantly increases the incidence of cardiovascular disease and all-cause mortality patients with chronic kidney disease(CKD), severely affecting their health and lifespan. However, the mechanisms underlying vascular calcification in CKD remain incompletely understood, and the available therapeutic agents are limited. Research has found that the transformation of vascular smooth muscle cells(VSMCs) from a contractile phenotype to an osteoblast-like phenotype is a key step in CKD-related vascular calcification. As research on the pathogenesis of calcification progresses, it has been demonstrated that bone morphogenetic protein(BMP) and silent information regulator(SIRT) signaling pathways can participate in the process of vascular calcification by regulating the osteogenic transdifferentiation of VSMCs. Traditional Chinese medicine(TCM) has accumulated a wealth of valuable experience in the prevention and treatment of kidney diseases over centuries. Modern research indicates that TCM, with its multi-pathway, multi-target, and low-toxicity properties, has shown certain advantages in the prevention and treatment of CKD-related vascular calcification and in improving patients' quality of life. Therefore, in this study, we will introduce the latest research progress of TCM in preventing and treating CKD-related vascular calcification, particularly focusing on the BMP and SIRT signaling pathways, with the aim of providing ideas for the clinical diagnosis and treatment of CKD-related vascular calcification with TCM and related basic research.

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来源期刊
Zhongguo Zhongyao Zazhi
Zhongguo Zhongyao Zazhi Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.50
自引率
0.00%
发文量
581
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