{"title":"5-羟色胺、瘦素和NE在早泄分类中的价值。","authors":"Zhimin Chen, Xiansheng Zhang","doi":"10.1093/sexmed/qfae086","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>While premature ejaculation (PE) can be divided into lifelong PE (LPE), acquired PE, natural variable PE (NPE), and subjective PE (SPE), there is no objective method to classify PE.</p><p><strong>Aim: </strong>To determine the value of serum serotonin (5-HT), leptin, and norepinephrine (NE) levels in the classification of PE.</p><p><strong>Methods: </strong>From July 2023 to July 2024, we recruited 150 participants and divided them into 4 groups: LPE (43 cases), NPE (32 cases), SPE (35 cases), and non-PE (40 cases) groups. All participants' baseline data, premature ejaculation diagnostic tool score, and intravaginal ejaculation latency time were investigated. In addition, all participants' serum 5-HT, leptin, and NE levels were measured.</p><p><strong>Outcome: </strong>Serum 5-HT, NE, and leptin levels were compared among all groups.</p><p><strong>Results: </strong>Serum 5-HT levels were lower and NE and leptin levels were higher in the LPE group compared to the SPE, NPE, and non-PE groups (<i>P</i> < .05). However, serum 5-HT, leptin, and NE levels were not significantly different among the non-PE, NPE, and SPE groups (<i>P</i> < .05). In addition, serum 5-HT <95.0 ng/mL, NE >543.0 ng/L, and leptin >19.8 ng/mL may be predictive indicators of LPE.</p><p><strong>Clinical significance: </strong>Based on serum 5-HT, NE, and leptin levels, LPE can be distinguished from SPE and NPE, which provides an objective basis for the treatment of PE.</p><p><strong>Strengths and limitations: </strong>There is no effective method to classify PE. The main limitation of this study is the limited sample size.</p><p><strong>Conclusion: </strong>The serum 5-HT, leptin, and NE levels in PE patients may contribute to the classification of PE.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 6","pages":"qfae086"},"PeriodicalIF":2.6000,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725958/pdf/","citationCount":"0","resultStr":"{\"title\":\"The value of 5-HT, leptin, and NE in the classification of premature ejaculation.\",\"authors\":\"Zhimin Chen, Xiansheng Zhang\",\"doi\":\"10.1093/sexmed/qfae086\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>While premature ejaculation (PE) can be divided into lifelong PE (LPE), acquired PE, natural variable PE (NPE), and subjective PE (SPE), there is no objective method to classify PE.</p><p><strong>Aim: </strong>To determine the value of serum serotonin (5-HT), leptin, and norepinephrine (NE) levels in the classification of PE.</p><p><strong>Methods: </strong>From July 2023 to July 2024, we recruited 150 participants and divided them into 4 groups: LPE (43 cases), NPE (32 cases), SPE (35 cases), and non-PE (40 cases) groups. All participants' baseline data, premature ejaculation diagnostic tool score, and intravaginal ejaculation latency time were investigated. In addition, all participants' serum 5-HT, leptin, and NE levels were measured.</p><p><strong>Outcome: </strong>Serum 5-HT, NE, and leptin levels were compared among all groups.</p><p><strong>Results: </strong>Serum 5-HT levels were lower and NE and leptin levels were higher in the LPE group compared to the SPE, NPE, and non-PE groups (<i>P</i> < .05). However, serum 5-HT, leptin, and NE levels were not significantly different among the non-PE, NPE, and SPE groups (<i>P</i> < .05). In addition, serum 5-HT <95.0 ng/mL, NE >543.0 ng/L, and leptin >19.8 ng/mL may be predictive indicators of LPE.</p><p><strong>Clinical significance: </strong>Based on serum 5-HT, NE, and leptin levels, LPE can be distinguished from SPE and NPE, which provides an objective basis for the treatment of PE.</p><p><strong>Strengths and limitations: </strong>There is no effective method to classify PE. 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引用次数: 0
摘要
背景：虽然早泄（PE）可分为终身性早泄（LPE）、获得性早泄（PE）、自然可变早泄（NPE）和主观性早泄（SPE），但目前尚无客观的方法对其进行分类。目的：探讨血清5-羟色胺（5-HT）、瘦素（leptin）和去甲肾上腺素（NE）水平在PE分型中的价值。方法：从2023年7月至2024年7月，我们招募了150名参与者，将其分为4组：LPE（43例）、NPE（32例）、SPE（35例）和非pe（40例）组。研究了所有参与者的基线数据、早泄诊断工具评分和阴道内射精潜伏期。此外，还测量了所有参与者的血清5-羟色胺、瘦素和NE水平。结果：比较各组血清5-羟色胺、NE和瘦素水平。结果：与SPE、NPE和非pe组相比，LPE组血清5-HT水平较低，NE和瘦素水平较高（P < 543.0 ng/L, P < 19.8 ng/mL），可能是LPE的预测指标。临床意义：根据血清5-HT、NE、瘦素水平，可将LPE与SPE、NPE区分开来，为PE的治疗提供客观依据。优势与局限性：目前尚无有效的PE分类方法。本研究的主要局限性是样本量有限。结论：PE患者血清5-HT、瘦素和NE水平可能有助于PE的分型。
The value of 5-HT, leptin, and NE in the classification of premature ejaculation.
Background: While premature ejaculation (PE) can be divided into lifelong PE (LPE), acquired PE, natural variable PE (NPE), and subjective PE (SPE), there is no objective method to classify PE.
Aim: To determine the value of serum serotonin (5-HT), leptin, and norepinephrine (NE) levels in the classification of PE.
Methods: From July 2023 to July 2024, we recruited 150 participants and divided them into 4 groups: LPE (43 cases), NPE (32 cases), SPE (35 cases), and non-PE (40 cases) groups. All participants' baseline data, premature ejaculation diagnostic tool score, and intravaginal ejaculation latency time were investigated. In addition, all participants' serum 5-HT, leptin, and NE levels were measured.
Outcome: Serum 5-HT, NE, and leptin levels were compared among all groups.
Results: Serum 5-HT levels were lower and NE and leptin levels were higher in the LPE group compared to the SPE, NPE, and non-PE groups (P < .05). However, serum 5-HT, leptin, and NE levels were not significantly different among the non-PE, NPE, and SPE groups (P < .05). In addition, serum 5-HT <95.0 ng/mL, NE >543.0 ng/L, and leptin >19.8 ng/mL may be predictive indicators of LPE.
Clinical significance: Based on serum 5-HT, NE, and leptin levels, LPE can be distinguished from SPE and NPE, which provides an objective basis for the treatment of PE.
Strengths and limitations: There is no effective method to classify PE. The main limitation of this study is the limited sample size.
Conclusion: The serum 5-HT, leptin, and NE levels in PE patients may contribute to the classification of PE.
期刊介绍：
Sexual Medicine is an official publication of the International Society for Sexual Medicine, and serves the field as the peer-reviewed, open access journal for rapid dissemination of multidisciplinary clinical and basic research in all areas of global sexual medicine, and particularly acts as a venue for topics of regional or sub-specialty interest. The journal is focused on issues in clinical medicine and epidemiology but also publishes basic science papers with particular relevance to specific populations. Sexual Medicine offers clinicians and researchers a rapid route to publication and the opportunity to publish in a broadly distributed and highly visible global forum. The journal publishes high quality articles from all over the world and actively seeks submissions from countries with expanding sexual medicine communities. Sexual Medicine relies on the same expert panel of editors and reviewers as The Journal of Sexual Medicine and Sexual Medicine Reviews.
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