靶向HBV cccDNA水平：实现慢性乙型肝炎完全治愈的关键

IF 3.3 3区医学 Q2 MICROBIOLOGY

Pathogens Pub Date : 2024-12-13 DOI:10.3390/pathogens13121100

Wei He, Zhijin Zheng, Qian Zhao, Renxia Zhang, Hui Zheng

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引用次数: 0

摘要

由HBV感染引起的慢性乙型肝炎（CHB）给许多人带来了痛苦。由于HBV复制的原始模板HBV cccDNA的稳定存在，慢性乙型肝炎（CHB）难以完全治愈。尽管目前的抗病毒策略能够有效地限制慢性乙型肝炎的进展，但完全治愈慢性乙型肝炎需要直接靶向HBV cccDNA。在这篇综述中，我们讨论了可能实现完全治愈CHB的策略，包括抑制cccDNA从头合成，通过宿主因子和小分子靶向cccDNA降解，基于crisp - cas9的cccDNA编辑，以及从表观遗传上沉默cccDNA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting HBV cccDNA Levels: Key to Achieving Complete Cure of Chronic Hepatitis B.

Chronic hepatitis B (CHB) caused by HBV infection has brought suffering to numerous people. Due to the stable existence of HBV cccDNA, the original template for HBV replication, chronic hepatitis B (CHB) is difficult to cure completely. Despite current antiviral strategies being able to effectively limit the progression of CHB, complete CHB cure requires directly targeting HBV cccDNA. In this review, we discuss strategies that may achieve a complete cure of CHB, including inhibition of cccDNA de novo synthesis, targeting cccDNA degradation through host factors and small molecules, CRISP-Cas9-based cccDNA editing, and silencing cccDNA epigenetically.

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来源期刊

Pathogens Medicine-Immunology and Allergy

CiteScore

6.40

自引率

8.10%

发文量

1285

审稿时长

17.75 days

期刊介绍： Pathogens (ISSN 2076-0817) publishes reviews, regular research papers and short notes on all aspects of pathogens and pathogen-host interactions. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodical details must be provided for research articles.