{"title":"局部注射透明质酸对皮肤衰老的影响：一项系统综述和荟萃分析。","authors":"Rongying Zhou, Mei Yu","doi":"10.1111/jocd.16760","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Aging reduces the production of hyaluronic acid (HA) in the skin, leading to wrinkles and sagging. HA-based skincare products are being studied to improve skin quality. This systematic review and meta-analysis aimed to compare the effectiveness of HA-based injectable products for reducing wrinkles and enhancing skin elasticity, hydration, and radiation.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Eligible trial reports were found by searching PubMed, Embase, Scopus, and Web of Science systematically until May 2024. A random-effects meta-analysis was performed to evaluate the effect of HA injection on skin aging. The protocol of the study has been registered in PROSPERO with a registration ID of CRD42024540703.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Overall, 12 studies met the inclusion criteria, of which 6 studies had enough data for meta-analysis. The random-effect meta-analysis showed improved hydration (SMD = 1.34, 95% CI = 0.14–2.54, and <i>p</i> < 0.05) and radiance (SMD = 0.51, 95% CI = 0.22–0.80, and <i>p</i> < 0.05) after HA filler injection. However, there was no significant difference in elasticity (SMD = 0.25, 95% CI = −0.20–0.70, and <i>p</i> = 0.27) and melanin index (SMD = −1.74, 95% CI = −4.89–1.41, <i>p</i> = 0.28) compared to controls.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>According to the results of a meta-analysis, hyaluronic acid injections have been found to improve skin hydration and radiance, thus reversing the effects of skin aging. However, the study did not find any significant changes in the skin's elasticity or melanin index. Further research is required to confirm the effectiveness of hyaluronic acid in treating skin aging.</p>\n </section>\n </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731322/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Effect of Local Hyaluronic Acid Injection on Skin Aging: A Systematic Review and Meta-Analysis\",\"authors\":\"Rongying Zhou, Mei Yu\",\"doi\":\"10.1111/jocd.16760\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Aging reduces the production of hyaluronic acid (HA) in the skin, leading to wrinkles and sagging. HA-based skincare products are being studied to improve skin quality. This systematic review and meta-analysis aimed to compare the effectiveness of HA-based injectable products for reducing wrinkles and enhancing skin elasticity, hydration, and radiation.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Eligible trial reports were found by searching PubMed, Embase, Scopus, and Web of Science systematically until May 2024. A random-effects meta-analysis was performed to evaluate the effect of HA injection on skin aging. The protocol of the study has been registered in PROSPERO with a registration ID of CRD42024540703.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Overall, 12 studies met the inclusion criteria, of which 6 studies had enough data for meta-analysis. The random-effect meta-analysis showed improved hydration (SMD = 1.34, 95% CI = 0.14–2.54, and <i>p</i> < 0.05) and radiance (SMD = 0.51, 95% CI = 0.22–0.80, and <i>p</i> < 0.05) after HA filler injection. However, there was no significant difference in elasticity (SMD = 0.25, 95% CI = −0.20–0.70, and <i>p</i> = 0.27) and melanin index (SMD = −1.74, 95% CI = −4.89–1.41, <i>p</i> = 0.28) compared to controls.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>According to the results of a meta-analysis, hyaluronic acid injections have been found to improve skin hydration and radiance, thus reversing the effects of skin aging. However, the study did not find any significant changes in the skin's elasticity or melanin index. 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引用次数: 0
摘要
背景：衰老会减少皮肤中透明质酸（HA）的产生，导致皱纹和下垂。人们正在研究以ha为基础的护肤品，以改善皮肤质量。本系统综述和荟萃分析旨在比较基于ha的注射产品在减少皱纹和增强皮肤弹性、水合作用和辐射方面的有效性。方法：截止2024年5月，系统检索PubMed、Embase、Scopus和Web of Science，找到符合条件的试验报告。随机效应荟萃分析评估透明质酸注射对皮肤老化的影响。本研究方案已在PROSPERO注册，注册ID为CRD42024540703。结果：总的来说，12项研究符合纳入标准，其中6项研究有足够的数据进行meta分析。随机效应荟萃分析显示，注射透明质酸可以改善皮肤的水合作用（SMD = 1.34, 95% CI = 0.14-2.54, p）。结论：根据荟萃分析的结果，注射透明质酸可以改善皮肤的水合作用和光泽，从而逆转皮肤衰老的影响。然而，该研究并未发现皮肤弹性或黑色素指数有任何显著变化。透明质酸治疗皮肤老化的有效性还需要进一步的研究来证实。
The Effect of Local Hyaluronic Acid Injection on Skin Aging: A Systematic Review and Meta-Analysis
Background
Aging reduces the production of hyaluronic acid (HA) in the skin, leading to wrinkles and sagging. HA-based skincare products are being studied to improve skin quality. This systematic review and meta-analysis aimed to compare the effectiveness of HA-based injectable products for reducing wrinkles and enhancing skin elasticity, hydration, and radiation.
Methods
Eligible trial reports were found by searching PubMed, Embase, Scopus, and Web of Science systematically until May 2024. A random-effects meta-analysis was performed to evaluate the effect of HA injection on skin aging. The protocol of the study has been registered in PROSPERO with a registration ID of CRD42024540703.
Results
Overall, 12 studies met the inclusion criteria, of which 6 studies had enough data for meta-analysis. The random-effect meta-analysis showed improved hydration (SMD = 1.34, 95% CI = 0.14–2.54, and p < 0.05) and radiance (SMD = 0.51, 95% CI = 0.22–0.80, and p < 0.05) after HA filler injection. However, there was no significant difference in elasticity (SMD = 0.25, 95% CI = −0.20–0.70, and p = 0.27) and melanin index (SMD = −1.74, 95% CI = −4.89–1.41, p = 0.28) compared to controls.
Conclusions
According to the results of a meta-analysis, hyaluronic acid injections have been found to improve skin hydration and radiance, thus reversing the effects of skin aging. However, the study did not find any significant changes in the skin's elasticity or melanin index. Further research is required to confirm the effectiveness of hyaluronic acid in treating skin aging.
期刊介绍：
The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques.
The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.
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