洞察 2 型糖尿病并发症的分子基础。

IF 3.1 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Human molecular genetics Pub Date : 2025-01-14 DOI:10.1093/hmg/ddae203

Archit Singh, Ozvan Bocher, Eleftheria Zeggini

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引用次数: 0

摘要

2 型糖尿病（T2D）并发症对全球健康构成重大挑战。人们已经利用组学技术来研究这些并发症，并确定其中涉及的生物通路。在这篇综述中，我们将重点关注 T2D 的四大并发症：糖尿病肾病、糖尿病视网膜病变、糖尿病神经病变和心血管并发症。我们讨论了全局组学研究的进展，总结了不同血统和疾病相关组织的基因组学、表观基因组学、转录组学、蛋白质组学和代谢组学研究的发现。我们强调了整合多组学技术以阐明 T2D 并发症的生物机制的重要性，并提倡进行祖先多样性研究。最终，这些见解将改善 T2D 并发症的风险预测，并为转化策略提供依据。

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Insights into the molecular underpinning of type 2 diabetes complications.

Type 2 diabetes (T2D) complications pose a significant global health challenge. Omics technologies have been employed to investigate these complications and identify the biological pathways involved. In this review, we focus on four major T2D complications: diabetic kidney disease, diabetic retinopathy, diabetic neuropathy, and cardiovascular complications. We discuss advancements in omics research, summarizing findings from genetic, epigenomic, transcriptomic, proteomic, and metabolomic studies across different ancestries and disease-relevant tissues. We stress the importance of integrating multi-omics techniques to elucidate the biological mechanisms underlying T2D complications and advocate for ancestrally diverse studies. Ultimately, these insights will improve risk prediction for T2D complications and inform translation strategies.

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来源期刊

Human molecular genetics 生物-生化与分子生物学

CiteScore

6.90

自引率

2.90%

发文量

294

审稿时长

2-4 weeks

期刊介绍： Human Molecular Genetics concentrates on full-length research papers covering a wide range of topics in all aspects of human molecular genetics. These include: the molecular basis of human genetic disease developmental genetics cancer genetics neurogenetics chromosome and genome structure and function therapy of genetic disease stem cells in human genetic disease and therapy, including the application of iPS cells genome-wide association studies mouse and other models of human diseases functional genomics computational genomics In addition, the journal also publishes research on other model systems for the analysis of genes, especially when there is an obvious relevance to human genetics.