血清炎症标志物在良性前列腺增生症中的临床应用价值研究

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-01-01 DOI:10.7754/Clin.Lab.2024.240607

Shuli Yu, Changhuan Zhang, Wei Zhang, Chunyan Qian, Xiangmin Tong, Hong Yuan

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引用次数: 0

摘要

研究背景本研究旨在探讨血清炎症标志物在老年男性良性前列腺增生症（BPH）诊断和治疗中的临床应用价值：方法：选取2023年4月至2023年7月在我院接受检查的110名良性前列腺增生症患者和120名健康人作为研究对象。测量两组患者的 C 反应蛋白（CRP）、降钙素原（PCT）、血清淀粉样蛋白 A（SAA）、补体 3（C3）和补体 4（C4）的浓度：结果：良性前列腺增生患者组的 CRP 和 SAA 浓度明显高于健康对照组（P < 0.05）。良性前列腺增生与 CRP 和 SAA 的浓度有明显相关性，但与 PCT、C3 或 C4 没有相关性。ROC 曲线分析表明，SAA 和 CRP 对良性前列腺增生症都有很高的诊断效力。此外，联合使用 SAA 和 CRP 的诊断效果更好。这种联合方法有望为医生指导诊断和治疗提供支持：结论：血清炎症标记物可作为良性前列腺增生症的独立因素。结论：血清炎症指标可作为良性前列腺增生症的独立因素，其中 CRP 和 SAA 与良性前列腺增生症呈显著正相关，这对良性前列腺增生症的无创诊断具有重要意义。

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Study on the Clinical Application Value of Serum Inflammatory Markers in Benign Prostatic Hyperplasia.

Background: The aim of this study was to explore the clinical application value of serum inflammatory markers in the diagnosis and treatment of benign prostatic hyperplasia (BPH) in elderly men.

Methods: From April 2023 through July 2023, 110 BPH patients and 120 healthy individuals who underwent examinations at our hospital were selected as study subjects. The concentrations of C-reactive protein (CRP), procalcitonin (PCT), serum amyloid A (SAA), complement 3 (C3), and complement 4 (C4) were measured in both groups.

Results: The concentrations of CRP and SAA in the BPH patient group were significantly higher than those in the healthy control group (p < 0.05). There was a significant correlation between BPH and the concentrations of CRP and SAA, but no correlation with PCT, C3, or C4. ROC curve analysis indicates that both SAA and CRP have high diagnostic efficacy for BPH. Furthermore, the combined use of SAA and CRP provides the better diagnostic performance. This combined approach has the potential to support physicians in guiding diagnosis and treatment.

Conclusions: Serum inflammatory markers can serve as independent factors for BPH. Among them, CRP and SAA are significantly positively correlated with BPH, which is of great significance for the non-invasive diagnosis of BPH.

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.