血管紧张素II与改性低密度脂蛋白复合物:对大鼠行为和血流动力学的影响。

IF 0.9 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
S M Tolpygo, B B Shoibonov, T S Zamolodchikova, A V Kotov
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引用次数: 0

摘要

内源性多修饰LDL (mLDL)和肾素-血管紧张素系统在动脉粥样硬化的发生发展中起重要作用。通过行为学和血流动力学参数发现血管紧张素II (Ang II)与mLDL联合使用的生理活性由于其利尿作用减弱和高血压和心动过速作用的逆转而明显改变。动脉粥样硬化是一个长期的病理过程,因此单次给药人工合成的Ang - I-mLDL复合物可以被认为是机体与致病因子第一次接触的模型。我们认为血管紧张素复合物与mLDL在动脉粥样硬化的初始阶段参与适应性和代偿机制,并在后来促进其进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Complex of Angiotensin II with Modified Low-Density Lipoproteins: Behavioral and Hemodynamic Effects in Rats.

Endogenous multiple modified LDL (mLDL) and the renin-angiotensin system play a significant role in the development of atherosclerosis. It has been found that by behavioral and hemodynamic parameters the physiological activity of angiotensin II (Ang II) in combination with mLDL is considerably modified due to weakening of its diuretic effect and the inversion of hypertensive and tachyarrhythmic effects. Atherosclerosis is a long-term pathological process, so a single administration of artificially synthesized Ang I-mLDL complexes can be considered a model of the first contact of the body with pathogenic factors. We believe that angiotensin complexes with mLDL participate in adaptive and compensatory mechanisms at the initial stages of atherosclerosis and later contribute to its progression.

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来源期刊
Bulletin of Experimental Biology and Medicine
Bulletin of Experimental Biology and Medicine 医学-医学:研究与实验
CiteScore
1.50
自引率
14.30%
发文量
265
审稿时长
2 months
期刊介绍: Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.
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