4-(het)芳基-4-氧-2-[（3-乙氧羰基-5,6,7,8-四氢- 4h -环庚[b]-噻吩-2-基）氨基]- 2-烯酸的合成、分子内环化及其抑菌活性

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-01-14 DOI:10.1007/s11172-024-4452-y

K. Yu. Parkhoma, E. D. Davydenkova, R. R. Makhmudov, I. A. Gorbunova, D. A. Shipilovskikh

引用次数: 0

摘要

开发了合成方法，拓宽了取代4-（六）芳基-2-[（3-乙氧基羰基-5,6,7,8-四氢- 4h -环庚[b]噻吩-2-基）氨基]-4-氧丁-2-烯酸的范围。研究了合成化合物的抗伤活性和急性毒性。结果表明，合成的取代酸具有明显的抗伤活性，实际上是无毒的。

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Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-4-oxo-2-[(3-ethoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]-thiophen-2-yl)amino]but-2-enoic acids

The synthetic procedure was developed and the scope of the substituted 4-(het)aryl-2-[(3-ethoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-4-oxobut-2-enoic acids was broadened. Antinociceptive activity and acute toxicity of the synthesized compounds were studied. It was found that the synthesized substituted acids show pronounced antinociceptive activity and were classified as being practically non-toxic.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.